CAJ | 학술논문

目的探讨非ST段抬高型心梗患者PCI术前加用曲美他嗪的疗效. 方法 59例单支血管病变的非ST段抬高型心肌梗死患者随机分为2组. 对照组29例,只接受常规治疗;曲美他嗪组30例,PCI术前给予60 mg曲美他嗪,之后给予20 mg,3次/d,持续用至术后1 个月. 观察两组患者左心室舒张末期容积、MPI、AD-MA、BNP的水平. 结果 PCI术前加用曲美他嗪能够更好地改善左心室舒张末期容积、MPI、ADMA、BNP. 结论 PCI术前加用曲美他嗪能够降低非ST段抬高型心肌梗死患者ADMA和BNP的浓度,改善左心室舒张末期容积和MPI,可能与改善患者预后相关.
목적 탐토비ST단태고형심경환자PCI술전가용곡미타진적료효. 방법 59례단지혈관병변적비ST단태고형심기경사환자수궤분위2조. 대조조29례,지접수상규치료;곡미타진조30례,PCI술전급여60 mg곡미타진,지후급여20 mg,3차/d,지속용지술후1 개월. 관찰량조환자좌심실서장말기용적、MPI、AD-MA、BNP적수평. 결과 PCI술전가용곡미타진능구경호지개선좌심실서장말기용적、MPI、ADMA、BNP. 결론 PCI술전가용곡미타진능구강저비ST단태고형심기경사환자ADMA화BNP적농도,개선좌심실서장말기용적화MPI,가능여개선환자예후상관.
Objective To investigate the efficacy of trimetazidine treatment for non-ST-segment elevation my-ocardial infarction patients undergoing percutaneous coronary intervention. Methods 59 patients were randomly divid-ed into control group (n=29) and trimetazidine group (n=30). Trimetazidine group received a loading dose of trime-tazidine 60 mg with conventional treatment before PCI,afterwards they received trimetazidine 20 mg tid till 1 month af-ter PCI therapy. Control group only received the conventional treatment. Serum ADMA and BNP concentrations, left ventricular end-diastolic volume and myocardial performance index were recorded. Results Compared with control group,serum ADMA and BNP concentrations,left ventricular end-diastolic volume and myocardial performance index were improved in trimetazidine group at 30 d after PCI. Conclusion The clinical improvement of trimetazidine treat-ment may be associated with decreasing ADMA and BNP levels,as well as the improvement of left ventricular end-di-astolic volume and MPI in non-ST segment elevation myocardial infarction patients.