CAJ | 학술논문

目的探讨盐酸舍曲林联合美沙拉秦治疗 UC 伴抑郁患者的疗效。方法纳入2014年3月至2015年3月的轻度 UC 活动期患者80例，抑郁自评量表（SDS）评分为＞53～70分。80例患者分成美沙拉秦联合舍曲林组和美沙拉秦组（对照组），每组40例。两组在纳入研究时和治疗后12周分别进行 SDS 问卷调查和胃肠镜检查，以判定疗效。统计学分析采用卡方检验或 t 检验。结果治疗后12周，美沙拉秦联合舍曲林组和美沙拉秦组的总体有效率分别为75％（30／40）和65％（26／40），差异无统计学意义（P ＞0．05）。治疗前，美沙拉秦联合舍曲林组和美沙拉秦组的溃疡性结肠炎活动指数（UCAI）分别为13．13±4．41和12．41±3．96；治疗后12周，两组的 UCAI 分别为7．29±5．78和8．60±4．56；两组均较治疗前的 UCAI 降低，差异均有统计学意义（t ＝6．1067、5．1893，P 均＜0．01），治疗后两组间 UCAI 差异无统计学意义（P＞0．05）。治疗前，美沙拉秦联合舍曲林组和美沙拉秦组的 SDS 评分分别为（55．98±9．61）和（56．27±8．45）分；治疗后12周，两组 SDS 评分分别为（49．36±4．51）和（52．81±6．11）分；与治疗前相比，治疗后12周美沙拉秦联合舍曲林组和美沙拉秦组的 SDS 评分均下降（t＝3．9440，P＝0．0002；t＝2．0986，P＝0．0391）；治疗后，美沙拉秦联合舍曲林组的 SDS 评分低于美沙拉秦组（t＝2．8732，P＝0．0052）。结论在 UC 常规治疗上加用盐酸舍曲林能明显改善 UC 患者的抑郁情绪，提高患者的生命质量。
목적탐토염산사곡림연합미사랍진치료 UC 반억욱환자적료효。방법납입2014년3월지2015년3월적경도 UC 활동기환자80례，억욱자평량표（SDS）평분위＞53～70분。80례환자분성미사랍진연합사곡림조화미사랍진조（대조조），매조40례。량조재납입연구시화치료후12주분별진행 SDS 문권조사화위장경검사，이판정료효。통계학분석채용잡방검험혹 t 검험。결과치료후12주，미사랍진연합사곡림조화미사랍진조적총체유효솔분별위75％（30／40）화65％（26／40），차이무통계학의의（P ＞0．05）。치료전，미사랍진연합사곡림조화미사랍진조적궤양성결장염활동지수（UCAI）분별위13．13±4．41화12．41±3．96；치료후12주，량조적 UCAI 분별위7．29±5．78화8．60±4．56；량조균교치료전적 UCAI 강저，차이균유통계학의의（t ＝6．1067、5．1893，P 균＜0．01），치료후량조간 UCAI 차이무통계학의의（P＞0．05）。치료전，미사랍진연합사곡림조화미사랍진조적 SDS 평분분별위（55．98±9．61）화（56．27±8．45）분；치료후12주，량조 SDS 평분분별위（49．36±4．51）화（52．81±6．11）분；여치료전상비，치료후12주미사랍진연합사곡림조화미사랍진조적 SDS 평분균하강（t＝3．9440，P＝0．0002；t＝2．0986，P＝0．0391）；치료후，미사랍진연합사곡림조적 SDS 평분저우미사랍진조（t＝2．8732，P＝0．0052）。결론재 UC 상규치료상가용염산사곡림능명현개선 UC 환자적억욱정서，제고환자적생명질량。
Objective To investigate the efficacy of sertraline hydrochloride combined with mesalazine in the treatment of patients with ulcerative colitis complicated with depression .Methods From March 2014 to March 2015 ,eighty patients with mild active ulcerative colitis ,self‐rating depression scale (SDS) score between > 53 and 70 points ,were enrolled .Eighty patients were divided into sertraline hydrochloride combined with mesalazine group and mesalazine group (control group) ,40 patients in each group .SDS questionnaire and gastrointestinal endoscopy were applied at the beginning of the study and 12 weeks after treatment to evaluate the efficacy .Chi square test or t test was performed for statistical analysis .Results After 12 weeks treatment ,the efficacy of mesalazine combined with sertraline group and mesalazine group was 75% (30/40) and 65% (26/40) , respectively ,and the difference was not statistically significant ( P > 0 .05 ) .Before the treatment ,ulcerative colitis activity index (UCAI) of mesalazine combined with sertraline group and mesalazine group was 13 .13 ± 4 .41 and 12 .41 ± 3 .96 , respectively ;12 weeks after treatment ,the UCAI of the two groups were 7 .29 ± 5 .78 and 8 .60 ± 4 .56 , respectively .The UCAI of both the two groups were lower than those before treatment , and the differences were statistically significant (t= 6 .106 7 and 5 .189 3 ,both P < 0 .01) .The difference was not statistically significant in UCAI between the two groups after treatment (P > 0 .05) .Before treatment ,SDS score of mesalazine combined with sertraline group and mesalazine group was 55 .98 ± 9 .61 and 56 .27 ± 8 .45 , respectively ;12 weeks after treatment ,SDS scores of the two groups were 49 .36 ± 4 .51 and 52 .81 ± 6 .11 ,respectively .Compared with those before treatment , after 12 weeks treatment , SDS scores of mesalazine combined with sertraline group and mesalazine group both decreased (t= 3 .944 0 ,P= 0 .000 2 ;t=2 .098 6 ,P= 0 .039 1) .After treatment ,SDS score of mesalazine combined with sertraline group was lower than that of mesalazine group (t = 2 .873 2 , P = 0 .005 2) .Conclusion Routine ulcerative colitis treatment combined with sertraline hydrochloride in ulcerative colitis can significantly improve depression of ulcerative colitis patients and improve the quality of patients′ life .