实用药物与临床
實用藥物與臨床
실용약물여림상
Practical Pharmacy and Clinical Remedies
2015年
9期
1070-1072
,共3页
抗精神病药%精神分裂症%疗效%安全性
抗精神病藥%精神分裂癥%療效%安全性
항정신병약%정신분렬증%료효%안전성
Antipsychotics%Schizophrenia%Efficacy%Safety
目的 研究喹硫平、阿立哌唑与氨磺必利治疗精神分裂症的疗效与安全性. 方法 选择2014年1-10月在我院精神科住院的300例精神分裂症患者,随机分为喹硫平组、阿立哌唑组、氨磺必利组,分别给予喹硫平[400~800 mg/d,平均(512 ±128)mg/d]、阿立哌唑[10~30 mg/d,平均(20 ±6)mg/d]、氨磺必利[400~800 mg/d,平均(635 ± 147)mg/d]治疗8周. 于分组前及治疗后4、8周用评估阳性和阴性症状量表(PANSS)、不良反应量表( TESS)评定疗效和不良反应,用社会功能量表( PSP)评定患者的社会功能. 结果 喹硫平组总有效率为68. 4%,阿立哌唑组总有效率为70.0%,氨磺必利组总有效率为69. 6%,三组总有效率比较,差异无统计学意义(P>0.05);三组患者CGI评分及PSP评分均显著增加. 结论 喹硫平、阿立哌唑与氨磺必利治疗精神分裂症的疗效相当,但不良反应特点不同.
目的 研究喹硫平、阿立哌唑與氨磺必利治療精神分裂癥的療效與安全性. 方法 選擇2014年1-10月在我院精神科住院的300例精神分裂癥患者,隨機分為喹硫平組、阿立哌唑組、氨磺必利組,分彆給予喹硫平[400~800 mg/d,平均(512 ±128)mg/d]、阿立哌唑[10~30 mg/d,平均(20 ±6)mg/d]、氨磺必利[400~800 mg/d,平均(635 ± 147)mg/d]治療8週. 于分組前及治療後4、8週用評估暘性和陰性癥狀量錶(PANSS)、不良反應量錶( TESS)評定療效和不良反應,用社會功能量錶( PSP)評定患者的社會功能. 結果 喹硫平組總有效率為68. 4%,阿立哌唑組總有效率為70.0%,氨磺必利組總有效率為69. 6%,三組總有效率比較,差異無統計學意義(P>0.05);三組患者CGI評分及PSP評分均顯著增加. 結論 喹硫平、阿立哌唑與氨磺必利治療精神分裂癥的療效相噹,但不良反應特點不同.
목적 연구규류평、아립고서여안광필리치료정신분렬증적료효여안전성. 방법 선택2014년1-10월재아원정신과주원적300례정신분렬증환자,수궤분위규류평조、아립고서조、안광필리조,분별급여규류평[400~800 mg/d,평균(512 ±128)mg/d]、아립고서[10~30 mg/d,평균(20 ±6)mg/d]、안광필리[400~800 mg/d,평균(635 ± 147)mg/d]치료8주. 우분조전급치료후4、8주용평고양성화음성증상량표(PANSS)、불량반응량표( TESS)평정료효화불량반응,용사회공능량표( PSP)평정환자적사회공능. 결과 규류평조총유효솔위68. 4%,아립고서조총유효솔위70.0%,안광필리조총유효솔위69. 6%,삼조총유효솔비교,차이무통계학의의(P>0.05);삼조환자CGI평분급PSP평분균현저증가. 결론 규류평、아립고서여안광필리치료정신분렬증적료효상당,단불량반응특점불동.
Objective To study the antipsychotic efficacy and safety of three kinds of drugs on patients with schizophrenia. Methods Patients with schizophrenia in our hospital from January to October in 2014 were selected and randomly divided into three groups,quetiapine group (n=98)accepted quetiapine 400 ~800 (512 ± 128)mg/d,aripi-prazole group (n=100) accepted aripiprazole 10~30 (20 ±6) mg/d,amisulpride group (n=102) accepted amisul-pride 400~800(635 ± 147) mg/d respectively for eight weeks. The efficacy and adverse reactions were evaluated by PANSS and TESS,and the social function was evaluated by PSP before and after 4 and 8 weeks of treatment. Results The total effective rate of quetiapine group,aripiprazole group and amisulpride group was 68. 4%,70.0% and 69. 6%respectively,there was no significant difference among the three groups(P>0.05). The score of CGI and PSP of each group increased significantly. Conclusion Quetiapine,aripiprazole and amisulpride have similar efficiency in the treat-ment of schizophrenic patients,but the adverse reactions features are different.
