CAJ | 학술논문

伴随医疗科技的迅猛发展，放疗成为癌症治疗的重要手段之一，但是放疗在减轻患者痛苦的同时也会给患者造成极大的副作用，其中放射性脑损伤已经成为限制放射性疗法临床上应用的一个重要因素。本研究采用30Gy Co60-γ射线一次性照射SD大鼠头部（身体其他部位用两层铅砖遮蔽），模拟放射性脑损伤的各个时期，建立既出现典型的损伤改变又不明显影响动物生存的放射性脑损伤模型。通过观察血液中氧化应激水平、细胞因子含量，脑组织中氧化应激水平、细胞因子含量、凋亡因子含量来分析脑损伤发生的可能机制。
반수의료과기적신맹발전，방료성위암증치료적중요수단지일，단시방료재감경환자통고적동시야회급환자조성겁대적부작용，기중방사성뇌손상이경성위한제방사성요법림상상응용적일개중요인소。본연구채용30Gy Co60-γ사선일차성조사SD대서두부（신체기타부위용량층연전차폐），모의방사성뇌손상적각개시기，건립기출현전형적손상개변우불명현영향동물생존적방사성뇌손상모형。통과관찰혈액중양화응격수평、세포인자함량，뇌조직중양화응격수평、세포인자함량、조망인자함량래분석뇌손상발생적가능궤제。
With the rapid development of medical science and technology, radiotherapy is an important measure of cancer therapy. Although radiotherapy can alleviate the suffering of patients, it also causes great side effects to patients at the same time. Radiation-induced brain injured has become an important factor that limits the clinical application of radiotherapy. In this research, we adoptsγ-ray one-time exposure the head of SD rats(other parts of the body with two layers of lead brick) to simulate various periods of radiation-induced brain injured.So that we can set up a model of radiation-induced brain injured which has typical damage change and do not signiifcantly affect the animals survival. And by observing the oxidative stress level and cytokine level in the blood, the oxidative stress level in brain tissue, the contents of cytokines and apoptosis factors to analyze the possible mechanism of brain injury.