实用药物与临床
實用藥物與臨床
실용약물여림상
Practical Pharmacy and Clinical Remedies
2015年
9期
1065-1069
,共5页
术后抑郁%相关因素分析%米氮平%盐酸氟西汀
術後抑鬱%相關因素分析%米氮平%鹽痠氟西汀
술후억욱%상관인소분석%미담평%염산불서정
Depression after operation%Analysis of related factors%Mirtazapine%Fluoxetine
目的 了解术后抑郁症状发生情况及影响因素,比较不同的药物干预治疗术后抑郁症状的疗效. 方法 调查263例纳入患者的住院资料,进行抑郁评估以及对医护人员的满意度调查;将肯定有抑郁症状的患者随机分为盐酸氟西汀组、米氮平组、联合组和对照组,疗程为2 ~3 个月. 结果 术后抑郁症状的发生率为42. 6%;术后抑郁症状好发于女性(r= -0.154,P=0.013)、18~45岁(r= -0.134,P=0.030)、术后病理为恶性(r= -0.248,P<0.001)、伴有术后疼痛(r= -0.629,P=0.027)、术后感染(r= -0.480,P<0.001)、少陪护(r=0.560,P<0.001)、对医护人员满意度差(r= -0.554,P<0.001)的患者,与手术部位无关(P>0.05);盐酸氟西汀组、米氮平组和联合组用药后抑郁评分均下降( P均<0.001 ) ,联合组下降程度高于单药组( P均<0.05 ). 结论 对于术后易发生抑郁症状的患者,合理的药物干预是必要的;盐酸氟西汀联合米氮平治疗术后存在抑郁症状的患者的疗效较好,不良反应较轻,值得临床推广应用.
目的 瞭解術後抑鬱癥狀髮生情況及影響因素,比較不同的藥物榦預治療術後抑鬱癥狀的療效. 方法 調查263例納入患者的住院資料,進行抑鬱評估以及對醫護人員的滿意度調查;將肯定有抑鬱癥狀的患者隨機分為鹽痠氟西汀組、米氮平組、聯閤組和對照組,療程為2 ~3 箇月. 結果 術後抑鬱癥狀的髮生率為42. 6%;術後抑鬱癥狀好髮于女性(r= -0.154,P=0.013)、18~45歲(r= -0.134,P=0.030)、術後病理為噁性(r= -0.248,P<0.001)、伴有術後疼痛(r= -0.629,P=0.027)、術後感染(r= -0.480,P<0.001)、少陪護(r=0.560,P<0.001)、對醫護人員滿意度差(r= -0.554,P<0.001)的患者,與手術部位無關(P>0.05);鹽痠氟西汀組、米氮平組和聯閤組用藥後抑鬱評分均下降( P均<0.001 ) ,聯閤組下降程度高于單藥組( P均<0.05 ). 結論 對于術後易髮生抑鬱癥狀的患者,閤理的藥物榦預是必要的;鹽痠氟西汀聯閤米氮平治療術後存在抑鬱癥狀的患者的療效較好,不良反應較輕,值得臨床推廣應用.
목적 료해술후억욱증상발생정황급영향인소,비교불동적약물간예치료술후억욱증상적료효. 방법 조사263례납입환자적주원자료,진행억욱평고이급대의호인원적만의도조사;장긍정유억욱증상적환자수궤분위염산불서정조、미담평조、연합조화대조조,료정위2 ~3 개월. 결과 술후억욱증상적발생솔위42. 6%;술후억욱증상호발우녀성(r= -0.154,P=0.013)、18~45세(r= -0.134,P=0.030)、술후병리위악성(r= -0.248,P<0.001)、반유술후동통(r= -0.629,P=0.027)、술후감염(r= -0.480,P<0.001)、소배호(r=0.560,P<0.001)、대의호인원만의도차(r= -0.554,P<0.001)적환자,여수술부위무관(P>0.05);염산불서정조、미담평조화연합조용약후억욱평분균하강( P균<0.001 ) ,연합조하강정도고우단약조( P균<0.05 ). 결론 대우술후역발생억욱증상적환자,합리적약물간예시필요적;염산불서정연합미담평치료술후존재억욱증상적환자적료효교호,불량반응교경,치득림상추엄응용.
Objective To investigate the incidence and related factors of depression after operation,and com-pare the efficacy on depression after operation improved by different drugs. Methods 263 cases were conducted by hospitalization data survey, depression evaluation and medical staff satisfaction survey. Depression patients were ran-domly divided into fluoxetine group,mirtazapine group,combined group and control group,and the course of treatment lasted for 2~3 months. Results The incidence of depression after operation was 42. 6%;depression after operation of-ten occurred in female (r= -0.154,P=0.013),18~45 years old (r= -0.134,P=0.030),malignant tumor (r= -0.248,P<0.001) postoperative pain(r= -0.629,P=0.027),postoperative infection(r= -0.480,P<0.001),less accompany (r=0.560,P<0.001),lower medical staff satisfaction (r= -0.554,P<0.001),and it had nothing to do with the operation site (P>0.05). Depression scores of fluoxetine group,mirtazapine group and combined group all decreased after treatment (P<0.001),and combined group decreased more obviously than the single drug groups(P<0.05). Conclusion For the patients prone to depression after operation,reasonable drug intervention is necessary;and the curative efficacy of fluoxetine combined with mirtazapine on depression after operation is better than that of single drug,and the adverse reactions are mild,it is worthy of clinical application.
