CAJ | 학술논문

利用与糖尿病肾病发生发展预后相关的生物学标记物，可以对这些患者做到早期筛查及分层管理，从而有助于改善患者的预后。目前指南推荐对于糖尿病肾病的诊断和分期应该基于白蛋白尿和肾小球滤过率的联合判断，但微量白蛋白尿的敏感性和特异性并不好，且肾小球滤过率在正常偏高水平时的准确检测较为困难。因此，很多学者致力于寻找更佳的关于糖尿病肾病的生物学标记物。目前的相关研究贯穿了代谢、炎症、氧化应激、晚期糖基化终末产物、纤维化、血管内皮功能、肾小管功能、遗传背景及足细胞损伤等多个领域，但很多方面还存在争议。（中华检验医学杂志，2015，38：583－585）
이용여당뇨병신병발생발전예후상관적생물학표기물，가이대저사환자주도조기사사급분층관리，종이유조우개선환자적예후。목전지남추천대우당뇨병신병적진단화분기응해기우백단백뇨화신소구려과솔적연합판단，단미량백단백뇨적민감성화특이성병불호，차신소구려과솔재정상편고수평시적준학검측교위곤난。인차，흔다학자치력우심조경가적관우당뇨병신병적생물학표기물。목전적상관연구관천료대사、염증、양화응격、만기당기화종말산물、섬유화、혈관내피공능、신소관공능、유전배경급족세포손상등다개영역，단흔다방면환존재쟁의。（중화검험의학잡지，2015，38：583－585）
Biomarkers can be applied in early diagnosis and classification for the development and progression of diabetic kidney disease ( DKD) , and thus are very useful in improving patients′prognosis. According to current relevant guidelines, the early screening and staging of DKD is based both on the level of urinary albumin excretion and glomerular filtration rate (GFR).However, the sensitivity and specificity of microalbuminuria recently has been challenged, and high-normal level GFR is difficult to be accurately measured.Therefore, many researchers devote themselves to seek more appropriate biomarkers for DKD. This is a controversial issue with its pros and cons, involving in metabolism, inflammation, oxidation, stress, advanced glycation end products, fibrosis, endothelium function, tubular function, genetic background, podocyte injury, and so on.