CAJ | 학술논문

在19世纪末人们就已经认识到，骨骼所处的力学状态改变时，骨内结构就会发生相应的变化和调整，并形成优化的承力结构。如何解释这种力致骨重建现象的细胞-分子机制是目前骨细胞力学方向的主要研究任务。本文综述了力学刺激作用下骨组织细胞的生物学响应，并分析了其所处的不同力学微环境，即基质变形、振动、流体剪切力、压力和微损伤等，对骨组织结构重建的影响。
재19세기말인문취이경인식도，골격소처적역학상태개변시，골내결구취회발생상응적변화화조정，병형성우화적승력결구。여하해석저충력치골중건현상적세포-분자궤제시목전골세포역학방향적주요연구임무。본문종술료역학자격작용하골조직세포적생물학향응，병분석료기소처적불동역학미배경，즉기질변형、진동、류체전절력、압력화미손상등，대골조직결구중건적영향。
Since the late 19th century it has been recognized that bone structure can be adapted to external mechanical loading. The mechanotransduction of bone cells is aiming to clarify the cellular and molecular mechanism of mechanically stimulated bone remodeling. This review summarizes the advances on the biological response of bone cells under mechanical stimulations, especially analyses the effect of different mechanical microenvironments on bone remodeling such as matrix deformation, vibration, lfuid shear stress, pressure and microdamage.