CAJ | 학술논문

苯是Ⅰ类致癌物。研究表明在慢性低剂量暴露下苯仍然具有血液毒性，识别苯血液毒性毒作用模式中关键事件有助于推动苯职业暴露限值的调整，因此，本文就苯环境暴露、代谢过程、靶器官、表观遗传、毒性效应及中毒结局6个方面对慢性低剂量暴露条件下与苯中毒过程相关的关键事件进行综述。
분시Ⅰ류치암물。연구표명재만성저제량폭로하분잉연구유혈액독성，식별분혈액독성독작용모식중관건사건유조우추동분직업폭로한치적조정，인차，본문취분배경폭로、대사과정、파기관、표관유전、독성효응급중독결국6개방면대만성저제량폭로조건하여분중독과정상관적관건사건진행종술。
Benzene is classified as Group 1 carcinogen by IARC. It has been found that benzene induces hematotoxicity even in low dose exposure. The identification of key events during benzene induced hematotoxicty leads to adjustment of occupational exposure limits of benzene. In this review, we focus on the exposure, metabolism, target organs, key epigenetic changes, toxicty effects and end points of low-dose chronic benzene exposure induced hematotoxicity and finally discuss the perspectives on the future study of this area.