CAJ | 학술논문

金属纳米材料已在各领域得到了广泛的应用，然而其存在的潜在风险仍不可忽视。本文就不同金属纳米材料遗传毒作用表现和毒效应机制方面的内容进行了探讨。金属纳米材料经多途径暴露进入机体，通过循环系统在多个脏器分布。金属纳米颗粒主要经胞吞作用进入细胞，在细胞内直接或经代谢后间接损伤遗传物质，影响细胞周期和基因组稳定性，造成基因突变、染色体畸变，甚至令细胞发生死亡或恶性转化。
금속납미재료이재각영역득도료엄범적응용，연이기존재적잠재풍험잉불가홀시。본문취불동금속납미재료유전독작용표현화독효응궤제방면적내용진행료탐토。금속납미재료경다도경폭로진입궤체，통과순배계통재다개장기분포。금속납미과립주요경포탄작용진입세포，재세포내직접혹경대사후간접손상유전물질，영향세포주기화기인조은정성，조성기인돌변、염색체기변，심지령세포발생사망혹악성전화。
Although metal nano materials have been widely used in various fields, the potential risks of it still could not be neglected. In this paper, the effects and mechanisms of genotoxicity caused by different nano materials were discussed. Human body can be exposed to metal nano materials through multiple pathways, metals nano follow the blood stream in circulatory system and distribute to organs. Metal nano particles are mainly uptaken into cells by endocytosis,and direct or indirect damages to genes can be induced by these particles after metabolism in cells. These damages would affect the course of cell cycle and the stability of the genome, resulting in gene mutation or chromosome aberration, and even leading to the death or malignant transformation of cells.