CAJ | 학술논문

目的：比较革兰阳性(G+)菌和革兰阴性(G-)菌血流感染(BSI)的血清降钙素原(PCT)水平，探讨血培养与PCT联合检测在临床诊断中的意义。方法：采用BD BACTEC9120型全自动血培养仪对199例住院发热患者的血液标本进行细菌培养，同时检测PCT水平，比较PCT浓度水平在血培养阳性与阴性之间以及革兰阳性细菌与阴性细菌之间的差异。结果：①筛选出检测PCT的99例血培养阳性标本中分别检出18种细菌，其中表皮葡萄球菌构成比最大(占17.2%)；其余依次为大肠埃希菌(占16.2%)和鲍曼不动杆菌(占10.1%)；②血培养阳性与血培养阴性标本PCT结果比较差异有统计学意义；③血培养革兰阳性菌与革兰阴性菌PCT结果比较无明显差异，但如果将革兰阳性菌组金黄色葡萄球菌的结果去除，再与革兰阴性菌相比差异有统计学意义。结论：PCT对革兰阴性菌与革兰阳性菌感染有一定的判别作用，配合血培养检测能辅助临床的快速诊断，提示临床初步抗生素的使用方向，减少用药的盲目性和耐药菌株的出现。
목적：비교혁란양성(G+)균화혁란음성(G-)균혈류감염(BSI)적혈청강개소원(PCT)수평，탐토혈배양여PCT연합검측재림상진단중적의의。방법：채용BD BACTEC9120형전자동혈배양의대199례주원발열환자적혈액표본진행세균배양，동시검측PCT수평，비교PCT농도수평재혈배양양성여음성지간이급혁란양성세균여음성세균지간적차이。결과：①사선출검측PCT적99례혈배양양성표본중분별검출18충세균，기중표피포도구균구성비최대(점17.2%)；기여의차위대장애희균(점16.2%)화포만불동간균(점10.1%)；②혈배양양성여혈배양음성표본PCT결과비교차이유통계학의의；③혈배양혁란양성균여혁란음성균PCT결과비교무명현차이，단여과장혁란양성균조금황색포도구균적결과거제，재여혁란음성균상비차이유통계학의의。결론：PCT대혁란음성균여혁란양성균감염유일정적판별작용，배합혈배양검측능보조림상적쾌속진단，제시림상초보항생소적사용방향，감소용약적맹목성화내약균주적출현。
Objective: Compare gram-positive (G+)bacteria and gram-negative bacteria (G-) bloodstream infections of serum procalcitonin(PCT) original level, to explore the clinical significance of blood culture and PCT joint detection. Methods: One hundred and ninty nine cases were selected, by using BD BACTEC 9120 type automatic blood culture instrument to detect the bacterial culture and at the same time the PCT results, comparative PCT concentration in blood cultures between positive and negative results and gram-positive bacteria and gram-negative bacteria. Results:(1)Screening detection of PCT were detected in 99 cases of specimens of blood culture positive for 18 species of bacteria including staphylococcus epidermis form than most, by 17.2%;The second is the e. coli were 16.2%and 10.1%acinetobacter baumannii. (2)blood culture positive for compared with the blood culture negative specimens of PCT difference was statistically significant. (3)blood culture gram-positive bacteria and gram-negative bacteria PCT results compare difference was not statistically significant, But if the group of gram-positive bacteria staphylococcus aureus results to remove from the group, compared with gram-negative bacteria difference was statistically significant. Conclusion:PCT of gram negative bacteria and gram positive bacterial infection has certain diagnostic role, with rapid diagnosis of clinical blood culture detection can be assisted, prompt clinical initial direction of the use of antibiotics, reduce blindness, reduce the emergence of resistant strains.