CAJ | 학술논문

目的分析参附注射液治疗脓毒血症的效果及影响因素,为进一步提高参附注射液的临床应用提供参考依据. 方法选取2011年1月至2014年1月我院ICU治疗的168例脓毒血症患者,以治疗过程中全程加用参附注射液的患者为病例组(82例),以未加用者为对照组(86例). 收集患者临床资料,应用Logistic回归分析参附注射液治疗脓毒血症的效果及影响因素. 结果治疗7 d内病例组好转45 例,迁延22 例,死亡15例;对照组好转35例,迁延25例,死亡26例. 两组比较差异有统计学意义(χ2 =8. 299,P=0.004). Logistic回归分析病例组的治疗效果优于对照组(OR=2. 557);患者APACHEⅡ评分、SIRS评分及C-反应蛋白(CRP)对疗效有影响. 结论参附注射液对脓毒血症患者有较好的治疗效果.
목적 분석삼부주사액치료농독혈증적효과급영향인소,위진일보제고삼부주사액적림상응용제공삼고의거. 방법 선취2011년1월지2014년1월아원ICU치료적168례농독혈증환자,이치료과정중전정가용삼부주사액적환자위병례조(82례),이미가용자위대조조(86례). 수집환자림상자료,응용Logistic회귀분석삼부주사액치료농독혈증적효과급영향인소. 결과 치료7 d내병례조호전45 례,천연22 례,사망15례;대조조호전35례,천연25례,사망26례. 량조비교차이유통계학의의(χ2 =8. 299,P=0.004). Logistic회귀분석병례조적치료효과우우대조조(OR=2. 557);환자APACHEⅡ평분、SIRS평분급C-반응단백(CRP)대료효유영향. 결론 삼부주사액대농독혈증환자유교호적치료효과.
Objective To investigate the effects and influence factors of shenfu injection in the treatment of serious sepsis by multivariate Logistic regression,so as to provide reference for clinical application. Methods 168 pa-tients with serious sepsis from January 2011 to January 2014 were retrospectively analyzed. Case group ( n=82 ) was defined as the administration of shenfu injection on the basis of Western medicine integrated treatment process,and con-trol group (n=86) was given Western medicine integrated treatment. Clinical data were reviewed and the potential in-fluence factors were analyzed by Logistic regression. Results 45 cases were improved,22 cases progressed and 15 ca-ses died in case group while 35 cases were improved,25 cases progressed and 26 cases died in control group after 7 d (χ2 =8. 299,P=0.004). Logistic regression analysis showed that therapeutic effects in case group was superior to con-trol group ( OR = 2. 557 ) and APACHE Ⅱ scores, CRP and SIRS scores would influence the therapeutic effects. Conclusion Shenfu injection has a better effect on serious sepsis.