实用药物与临床
實用藥物與臨床
실용약물여림상
Practical Pharmacy and Clinical Remedies
2015年
9期
1052-1055
,共4页
沙利度胺%老年性瘙痒症%小剂量
沙利度胺%老年性瘙癢癥%小劑量
사리도알%노년성소양증%소제량
Thalidomide%Senile pruritus%Low dose
目的 研究口服小剂量沙利度胺治疗老年性瘙痒症的疗效. 方法 将75例老年性瘙痒症患者随机分为2组. 治疗组口服沙利度胺75 mg,每晚1次;对照组口服盐酸左西替利嗪片5 mg,每晚1次. 分别于治疗前、治疗4周时进行瘙痒评分,治疗后观察两组疗效及安全性. 结果 治疗组和对照组治疗前瘙痒评分分别为8. 36 ± 2. 89、8. 24 ± 2. 32,差异无统计学意义(P >0.05),治疗后治疗组瘙痒评分低于照组(3. 71 ± 1. 92 vs. 5. 45 ± 2. 11),差异有统计学意义(t=3. 74,P<0.01),治疗组总有效率为86. 8%,对照组为43. 2%,治疗组明显优于对照组(χ2 =15. 73,P<0.01). 结论 应用小剂量沙利度胺治疗老年性瘙痒症的疗效良好,值得进一步研究及推广应用.
目的 研究口服小劑量沙利度胺治療老年性瘙癢癥的療效. 方法 將75例老年性瘙癢癥患者隨機分為2組. 治療組口服沙利度胺75 mg,每晚1次;對照組口服鹽痠左西替利嗪片5 mg,每晚1次. 分彆于治療前、治療4週時進行瘙癢評分,治療後觀察兩組療效及安全性. 結果 治療組和對照組治療前瘙癢評分分彆為8. 36 ± 2. 89、8. 24 ± 2. 32,差異無統計學意義(P >0.05),治療後治療組瘙癢評分低于照組(3. 71 ± 1. 92 vs. 5. 45 ± 2. 11),差異有統計學意義(t=3. 74,P<0.01),治療組總有效率為86. 8%,對照組為43. 2%,治療組明顯優于對照組(χ2 =15. 73,P<0.01). 結論 應用小劑量沙利度胺治療老年性瘙癢癥的療效良好,值得進一步研究及推廣應用.
목적 연구구복소제량사리도알치료노년성소양증적료효. 방법 장75례노년성소양증환자수궤분위2조. 치료조구복사리도알75 mg,매만1차;대조조구복염산좌서체리진편5 mg,매만1차. 분별우치료전、치료4주시진행소양평분,치료후관찰량조료효급안전성. 결과 치료조화대조조치료전소양평분분별위8. 36 ± 2. 89、8. 24 ± 2. 32,차이무통계학의의(P >0.05),치료후치료조소양평분저우조조(3. 71 ± 1. 92 vs. 5. 45 ± 2. 11),차이유통계학의의(t=3. 74,P<0.01),치료조총유효솔위86. 8%,대조조위43. 2%,치료조명현우우대조조(χ2 =15. 73,P<0.01). 결론 응용소제량사리도알치료노년성소양증적료효량호,치득진일보연구급추엄응용.
Objective To study the efficacy of oral low dose thalidomide in the treatment of senile pruri-tus. Methods 75 patients with senile pruritus were randomly divided into two groups. Patients in treatment group took 75 mg of thalidomide every night,while patients in control group took 5 mg of levocetirizine hydrochloride tablets every night. Score of itching was assessed before and after 4-week treatment. Efficacy and safety were evaluated after treat-ment. Results Itching score of treatment group and control group before receiving treatment was 8. 36 ± 2. 89 and 8. 24 ±2. 32,there was no significant difference between the two groups (P>0.05). Itching score of treatment group was lower than that of control group (3. 71 ± 1. 92 vs. 5. 45 ± 2. 11),there was significant difference between the two groups(t=3. 74,P<0.01). The overall response rate of treatment group was significantly higher than that of control group (86. 8% vs. 43. 2%,χ2 =15. 73,P<0.01). Conclusion Low dose thalidomide has a promising therapy effect in the treatment of senile pruritus. It is worthy of further studies and applications in clinic.
