CAJ | 학술논문

目的：了解儿童氯氮平药物中毒的临床情况，探讨儿童氯氮平血药浓度与血液灌流之间的相互关系，为进一步防范和抢救治疗提供参考。方法对22例服用氯氮平儿童临床资料进行调查，对患者年龄、误服剂量、血液灌流疗效等进行统计分析。结果22例儿童经过治疗，治愈13.6%，好转86.4%。血液灌流前后比较，氯氮平的浓度平均下降（280.8±180.2）ng·mL-1，前后浓度具有显著性差异（P<0.05）。灌流组与非灌流组的清醒所需时间分别为（25.8±1.5）h和（34.8±4.1）h，存在显著差异（P<0.05）。结论儿童氯氮平中毒均为误服，临床药师应及时宣讲贮藏药物安全知识，避免类似事件发生。根据氯氮平的血药浓度监测结果以及临床症状，及时进行血液灌流，能有效减少患儿清醒所需时间。
목적：료해인동록담평약물중독적림상정황，탐토인동록담평혈약농도여혈액관류지간적상호관계，위진일보방범화창구치료제공삼고。방법대22례복용록담평인동림상자료진행조사，대환자년령、오복제량、혈액관류료효등진행통계분석。결과22례인동경과치료，치유13.6%，호전86.4%。혈액관류전후비교，록담평적농도평균하강（280.8±180.2）ng·mL-1，전후농도구유현저성차이（P<0.05）。관류조여비관류조적청성소수시간분별위（25.8±1.5）h화（34.8±4.1）h，존재현저차이（P<0.05）。결론인동록담평중독균위오복，림상약사응급시선강저장약물안전지식，피면유사사건발생。근거록담평적혈약농도감측결과이급림상증상，급시진행혈액관류，능유효감소환인청성소수시간。
Objective To study the clinical manifestation of clozapine poisoning and discuss the relationship of clozapine blood concentration and hemoperfusion, so as to reduce clozapine poisoning and provide better rescue measures. Methods Clinical data of 22 patients who took clozapine were collected and analyzed in terms of patients' age, dosage, medical test results and hemoperfusion effect. Results After treatment, 13.6% patients were cured, 86.4%patients were improved. After hemoperfusion, the blood concentration of clozapine declined(280.8±180.2) ng·mL-1, and there is a significant difference before and after hemoperfusion(P<0.05). Besides, the time needed for waking of perfusion group and non-perfusion group was (25.8±1.5) h and (34.8±4.1)h respectively (P<0.05). Conclusion All the children poisoned were accidental, clinical pharmacist should explain and publicize the safety way to preserve drugs , and avoid poisoning accidents . In this study , clinical doctors can make a decision to take hemoperfusion measures timely according to blood concentration of clozapine and clinical manifestation, reduce the time needed for waking of patients.