CAJ | 학술논문

癌症的快速、准确血液诊断是国际生命健康领域亟待解决的科学问题。然而，现有临床诊断技术存在操作流程繁复、技术要求高、耗时长且成本昂贵等缺陷。发展可用于快速捕捉血液癌标志物的简易、经济型诊断新工具逐渐成为国内外学术研究热点。分子探针具备构建简易、响应快、成本低的优势，其传统应用领域为环境检测与细胞、活体标记等。近年来，灵敏探测血液癌标志物的分子探针创制，形成了一个多学科交叉的新兴领域。该文简要综述了相关领域研究团队对此类分子探针的构筑策略，并结合相关癌标志物的“快速检测”实例展现了探针的医学潜能，旨在为分子探针的多元化发展提供新的研究思路，期待通过独特化学技术与临床医学的有机结合，实现对癌症血液诊断的提速和低成本化。
암증적쾌속、준학혈액진단시국제생명건강영역극대해결적과학문제。연이，현유림상진단기술존재조작류정번복、기술요구고、모시장차성본앙귀등결함。발전가용우쾌속포착혈액암표지물적간역、경제형진단신공구축점성위국내외학술연구열점。분자탐침구비구건간역、향응쾌、성본저적우세，기전통응용영역위배경검측여세포、활체표기등。근년래，령민탐측혈액암표지물적분자탐침창제，형성료일개다학과교차적신흥영역。해문간요종술료상관영역연구단대대차류분자탐침적구축책략，병결합상관암표지물적“쾌속검측”실례전현료탐침적의학잠능，지재위분자탐침적다원화발전제공신적연구사로，기대통과독특화학기술여림상의학적유궤결합，실현대암증혈액진단적제속화저성본화。
The rapid yet accurate diagnosis of cancer is a critical issue that poses a great challenge worldwide in the ifeld of life science. However, current clinical biochemical techniques have lfaws in terms of complicated conducting procedures, high technical requirement, long detection time and high cost. The development of simpler and more economic tools for the fast blood tests of cancer biomarkers has become a major focus of the academy. Molecular probes have merits in sensing applications owing to their conciseness in construction, fast response and low cost. Their conventional application areas involve environmental analysis and cellular/in vivo imaging. In recent years, the development of molecular probes suitable for probing cancer biomarkers has become a vividly new multidisciplinary research ifeld. Here we summarize the construction strategies of these probes and highlight their diagnostic efifciency for cancer biomarkers. This article aims at spurring the diversiifcation of simple and effective molecular probes for the detection cancer biomarkers, accelerating the progress of cancer blood tests by the combination of chemical techniques with medicinal science.