CAJ | 학술논문

目的：探讨血糖波动与2型糖尿病（T2DM）下肢血管病变（PVD）严重程度的相关性。方法2型糖尿病合并下肢血管病变患者98例，根据踝肱指数（ABI），以0.7<ABI<0.9、0.5<ABI≤0.7、ABI≤0.5分为轻、中、重度组。所有患者均采用动态血糖检测系统（CGMS）连续监测患者血糖72h，计算各血糖波动参数，包括平均血糖水平（MBG）、全天血糖水平标准差（SDBG）、日内平均血糖波动幅度（MAGE）和血糖波动最大幅度（LAGE），并记录患者年龄、性别、病程、体重指数（BMI）、血压、糖化血红蛋白（HbA1c）及一般生化指标。结果各组间MBG、SDBG、MAGE的差异比较有统计学意义，随着下肢血管病变严重程度的增加而增加（P<0.05），下肢血管病变严重程度分别与MBG、MAGE呈正相关（β=0.238、0.187，P<0.05）。结论血糖波动与糖尿病下肢血管病变程度关系密切，应重视平稳降糖。
목적：탐토혈당파동여2형당뇨병（T2DM）하지혈관병변（PVD）엄중정도적상관성。방법2형당뇨병합병하지혈관병변환자98례，근거과굉지수（ABI），이0.7<ABI<0.9、0.5<ABI≤0.7、ABI≤0.5분위경、중、중도조。소유환자균채용동태혈당검측계통（CGMS）련속감측환자혈당72h，계산각혈당파동삼수，포괄평균혈당수평（MBG）、전천혈당수평표준차（SDBG）、일내평균혈당파동폭도（MAGE）화혈당파동최대폭도（LAGE），병기록환자년령、성별、병정、체중지수（BMI）、혈압、당화혈홍단백（HbA1c）급일반생화지표。결과각조간MBG、SDBG、MAGE적차이비교유통계학의의，수착하지혈관병변엄중정도적증가이증가（P<0.05），하지혈관병변엄중정도분별여MBG、MAGE정정상관（β=0.238、0.187，P<0.05）。결론혈당파동여당뇨병하지혈관병변정도관계밀절，응중시평은강당。
ObjectiveTo investigate the relationship between blood glucose fluctuation and peripheral vascular disease in type 2 diabetic patients.Methods98 hospitalized patients with T2DM having peripheral vascular disease were divided into mild,moderate and severe groups according to ankle brachial index(0.7<ABI<0.9、0.5<ABI≤0.7、ABI≤0.5). The fluctuating feature of 72 hours blood glucose of all the patients were recorded by continuous glucose monitoring system(CGMS),then CGMS parameters including mean blood glucose(GBG),standard deviation of blood glucose(SDBG),mean amplitude of glycemic excursions(MAGE) and maximal amlpitude of glycemic excursions(LAGE) were calculated and the age,gender,disease duration,BMI,blood pressure,HbA1c and biochemical indicators were also recorded.ResultsThere were significant difference in MBG,SDBG,MAGE among groups and MBG,SDBG,MAGE increases with growing severity of the vascular disease (P<0.05). The severity of the vascular disease was positively correlated with MBG and MAGE(β=0.238、0.187,P<0.05).ConclusionBlood glucose fluctuation is closely associated with the severity of peripheral vascular disease,so clinical protocols should be aimed at steadily reducing glucose level.