CAJ | 학술논문

目的：探讨急性心肌梗死患者血清谷氨酰转移酶（γ-GGT）水平与经皮冠状动脉介入治疗（PCI）术后冠状动脉无复流的相关性。方法急性心肌梗死并行急诊PCI的患者282例，根据冠状动脉造影心肌梗死溶栓治疗（TIMI）评分分为再灌注组（264例）和无复流组（18例），比较包括γ-GGT在内的血常规和生化的部分指标并进行统计学分析。结果无复流组中左室射血分数、白细胞总数、中性粒细胞值、中性粒细胞/淋巴细胞比值、血糖、γ-GGT、应用主动脉球囊反搏术与再灌注组比较，差异有统计学意义（P<0.05）。且无复流组患者住院期间的主要心脏不良事件的发生率（22.2%）与再灌注组比较，差异有统计学意义（P<0.05）。结论γ-GGT可能为急性心肌梗死患者PCI术后冠状动脉无复流发生的危险因素。
목적：탐토급성심기경사환자혈청곡안선전이매（γ-GGT）수평여경피관상동맥개입치료（PCI）술후관상동맥무복류적상관성。방법급성심기경사병행급진PCI적환자282례，근거관상동맥조영심기경사용전치료（TIMI）평분분위재관주조（264례）화무복류조（18례），비교포괄γ-GGT재내적혈상규화생화적부분지표병진행통계학분석。결과무복류조중좌실사혈분수、백세포총수、중성립세포치、중성립세포/림파세포비치、혈당、γ-GGT、응용주동맥구낭반박술여재관주조비교，차이유통계학의의（P<0.05）。차무복류조환자주원기간적주요심장불량사건적발생솔（22.2%）여재관주조비교，차이유통계학의의（P<0.05）。결론γ-GGT가능위급성심기경사환자PCI술후관상동맥무복류발생적위험인소。
Objectives To discuss the correlation ofγ-GGT levels and coronary no-reflow after percutaneous coronary intervention in patients with acute myocardial infarction.MethodsSelect 282 patients with acute myocardial infarction undergone primary percutaneous coronary intervention from September 2013 to March 2014 .According to thrombolysis in myocardial infarction ratings in coronary angiography,these patients were divided into reperfusion group(264 cases) and no-reflow group(18 cases). Compareγ-GGT and some other biochemical indicators and carry out statistical analysis.ResultsComparing to the reperfusion group,patients in no-reflow group had a worse level of left ventricular ejection fraction(EF values,0.456±0.073),WBC(10.946±5.513),neutrophil values(9.047±5.587),neutrophil / lymphocyte ratio (10.169±12.366),glucose(9.074±4.091),γ-GGT(48.50±30.924),preoperative use of intra-aortic balloon counter-pulsation(IABP) (3(16.7%)). The difference was statistically significant(P<0.05). Furthermore,occurrence rates of major adverse cardiac events(MACE) in no-reflow group(22.2%) were higher than reperfusion group(6.1%). The difference was also statistically significant(P=0.032,<0.05). Conclusionγ-GGT maybe a new indicator of coronary no-reflow after percutaneous coronary intervention in patients with acute myocardial infarction.