CAJ | 학술논문

目的：探讨磁共振弥散张量成像（DTI）在抑郁症患者额叶深部白质各向异性分数（FA）值异常变化的特点。方法中度以上抑郁症患者109例（观察组）和性别年龄匹配的健康志愿者89例（对照组），采用1.5T磁共振成像仪进行DTI检查，应用SPM2分析软件，采用基于体素的分析方法，比较中度以上抑郁症患者额叶扣带回FA值的变化。结果中度以上抑郁症患者额叶扣带回FA值明显低于正常对照组（P<0.01）。结论1.5TMR DTI发现中度以上抑郁症患者额叶深部白质存在微观的病理改变。
목적：탐토자공진미산장량성상（DTI）재억욱증환자액협심부백질각향이성분수（FA）치이상변화적특점。방법중도이상억욱증환자109례（관찰조）화성별년령필배적건강지원자89례（대조조），채용1.5T자공진성상의진행DTI검사，응용SPM2분석연건，채용기우체소적분석방법，비교중도이상억욱증환자액협구대회FA치적변화。결과중도이상억욱증환자액협구대회FA치명현저우정상대조조（P<0.01）。결론1.5TMR DTI발현중도이상억욱증환자액협심부백질존재미관적병리개변。
ObjectiveTo detect Fractional anisotropy(FA) characteristic of frontal white matter abnormalities in patients with major depressive disorder(MDD) by diffusion tensor imaging(DTI).Methods109 patients with MDD and 89 normal sex and age- matched volunteers underwent diffusion tensor imaging(DTI) with 1.5T MRI. The comparison of FA value was processed by voxel- based method using SPM2 in whole brain between the two groups.ResultsPatients with MDD showed significantly lower FA value in frontal white matter compared with the control group. Conclusions The microscopic pathological changes of frontal white matter in Patients with MDD may be founded by diffusion tensor imaging(DTI) with 1.5T MRI.