浙江临床医学
浙江臨床醫學
절강림상의학
Zhejiang Clinical Medical Journal
2015年
9期
1479-1480,1482
,共3页
大肠癌%解偶联蛋白2%临床症状%生存率
大腸癌%解偶聯蛋白2%臨床癥狀%生存率
대장암%해우련단백2%림상증상%생존솔
Colorectal cancer%UCP2%Clinical symptoms%Survival
目的:检测大肠癌组织中解偶联蛋白2(UCP2)的表达与分布,探讨其在大肠癌的发生发展、浸润转移中的作用。方法采用免疫组化方法检测正常大肠黏膜、大肠管状腺瘤、大肠癌中UCP2的表达。结果 UCP2在正常大肠黏膜、大肠管状腺瘤、大肠癌中的阳性表达量呈递增趋势,组间差异均有统计学意义(P<0.05);大肠癌中UCP2的表达与癌组织的浸润深度、淋巴转移、脉管内癌栓相关(P<0.05);大肠癌中UCP2的表达是影响患者术后生存的独立危险因素。结论 UCP2在大肠癌组织中高表达,可能与大肠癌的发生发展、浸润转移、预后密切相关。
目的:檢測大腸癌組織中解偶聯蛋白2(UCP2)的錶達與分佈,探討其在大腸癌的髮生髮展、浸潤轉移中的作用。方法採用免疫組化方法檢測正常大腸黏膜、大腸管狀腺瘤、大腸癌中UCP2的錶達。結果 UCP2在正常大腸黏膜、大腸管狀腺瘤、大腸癌中的暘性錶達量呈遞增趨勢,組間差異均有統計學意義(P<0.05);大腸癌中UCP2的錶達與癌組織的浸潤深度、淋巴轉移、脈管內癌栓相關(P<0.05);大腸癌中UCP2的錶達是影響患者術後生存的獨立危險因素。結論 UCP2在大腸癌組織中高錶達,可能與大腸癌的髮生髮展、浸潤轉移、預後密切相關。
목적:검측대장암조직중해우련단백2(UCP2)적표체여분포,탐토기재대장암적발생발전、침윤전이중적작용。방법채용면역조화방법검측정상대장점막、대장관상선류、대장암중UCP2적표체。결과 UCP2재정상대장점막、대장관상선류、대장암중적양성표체량정체증추세,조간차이균유통계학의의(P<0.05);대장암중UCP2적표체여암조직적침윤심도、림파전이、맥관내암전상관(P<0.05);대장암중UCP2적표체시영향환자술후생존적독립위험인소。결론 UCP2재대장암조직중고표체,가능여대장암적발생발전、침윤전이、예후밀절상관。
Purpose To explore the role and clinical significance of UCP2 in the development,infiltration andmetastasis of colorectal adenocarcinoma.Methodsthe expression of UCP2 in normal colorectal tissue,colorectal adenoma and colorectal adenocarcinoma were detected by immunohistochemical analysis.ResultsThe Results of immunohistochemistry showed the difference of UCP2 proteins positive expression among the normal colorectal tissue,the colorectal adenoma and the colorectal adenocarcinoma were signifi cant(P<0.05). the positive expression of UCP2 was closely correlated with depth of tumor infi ltration、metastasis of lymph node and Intravascular cancer embolus(P<0.05).The positive expression of UCP2 was independent risk factors for survial in patients with carcinoma of large intestine after operation.ConclusionUCP2 may play an important role in tumorigenesis,infi ltration and metastasis of colorectal adenocarcinoma.