CAJ | 학술논문

目的：研究β-榄香烯对小鼠乳腺癌移植瘤放疗增敏效果以及对乳腺癌移植瘤血管形成的影响。方法采用随机数表法将64只雌性小鼠分为8组，空白对照组（生理盐水组）、3个质量浓度（100，50，25 mg· kg-1）β-榄香烯组、放射组（仅给予放疗）、3个质量浓度（100，50，25 mg· kg-1）β-榄香烯分别联合放疗组，计算肿瘤生长时间及增敏系数。并对几组的移植瘤组织进行血管内皮生长因子（ VEGF）和微血管密度（ MVD）的表达情况进行观察。结果与空白对照组比较，各组的移植瘤明显生长（ P＜0.05）。在移植瘤的增倍时间、增敏系数上，各组同样存在差异（P＜0.05），其中50 mg· kg-1β-榄香烯联合放疗组的抑制效果更加明显。结论50mg·kg-1β-榄香烯可作为乳腺癌放疗的有效增敏剂，同时可有效的降低VEGF和 MVD的表达，从而抑制肿瘤内微血管的形成。
목적：연구β-람향희대소서유선암이식류방료증민효과이급대유선암이식류혈관형성적영향。방법채용수궤수표법장64지자성소서분위8조，공백대조조（생리염수조）、3개질량농도（100，50，25 mg· kg-1）β-람향희조、방사조（부급여방료）、3개질량농도（100，50，25 mg· kg-1）β-람향희분별연합방료조，계산종류생장시간급증민계수。병대궤조적이식류조직진행혈관내피생장인자（ VEGF）화미혈관밀도（ MVD）적표체정황진행관찰。결과여공백대조조비교，각조적이식류명현생장（ P＜0.05）。재이식류적증배시간、증민계수상，각조동양존재차이（P＜0.05），기중50 mg· kg-1β-람향희연합방료조적억제효과경가명현。결론50mg·kg-1β-람향희가작위유선암방료적유효증민제，동시가유효적강저VEGF화 MVD적표체，종이억제종류내미혈관적형성。
Objective To explore the sensitizing effect of β-elemene on breast cancer xenografts in mice and its the affect on angiogenesis of breast cancer xenografts .Methods Of 64 female mice using on a ran-dom number table divided into eight groups:blank control group , high, middle, low doses(100,50,25 mg· kg -1) of β-elemene groups, ra-diotherapy group , three combination groups ( 100 ,50 ,25 mg · kg -1 of β-elemene plus radiotherapy , respectively ) .The computing time and sensitizing tumor growth factor were calculated .And the expression of vascular endothelial growth factor ( VEGF ) and microvessel density ( MVD) were investigated.Results Compared with the blank control group from the growth curve , that tumor growth in each group there is a clear difference ( P<0.05 ) .The tumor doubling time and same sensiti-zing factor in each group were differences ( P <0.05 ) . The results suggest that 50 mg· kg -1β-elemene plus radiotherapy group was signifi-cantly better inhibition.Conclusion β-elemene ( 50 mg · kg -1 ) is effective as breast cancer radiotherapy sensitizers , and can effectively reduce the expression of VEGF and MVD , thereby inhibiting the formation of tumor microvessels.