实用检验医师杂志
實用檢驗醫師雜誌
실용검험의사잡지
Chinese Journal of Laboratory Pathologist
2015年
3期
153-157
,共5页
鲍曼不动杆菌%广泛耐药%药物敏感试验%抗菌药物%变化趋势
鮑曼不動桿菌%廣汎耐藥%藥物敏感試驗%抗菌藥物%變化趨勢
포만불동간균%엄범내약%약물민감시험%항균약물%변화추세
Acinetobacter baumannii%Extensive drug resistance%Drug sensitive test%Antibacterial agents%Change trend
目的：了解我院2009年-2013年鲍曼不动杆菌的检出情况和耐药变化趋势，为临床合理使用抗菌药物提供实验室依据。方法收集我院2009年1月-2013年12月住院患者分离的鲍曼不动杆菌4373株，对其各年检出情况和耐药情况进行分析。结果我院2009年-2013年分别检出鲍曼不动杆菌790株（8.95％）、812株（9.02％）、872株（9.04％）、1025株（11.72％）和874株（11.04％），其中广泛耐药鲍曼不动杆菌分别为364株（46.08％）、402株（49.51％）、446株（51.15％）、565株（55.12％）和579株（66.25％）。4373株鲍曼不动杆菌以痰液标本检出率最高（87.50％）；临床科室分布以呼吸重症科（36.57％）、ICU（31.95％）和呼吸内科（7.55％）为主；4373株鲍曼不动杆菌耐药情况严重，对青霉素类、头孢菌素类、喹诺酮类、磺胺类和单环β-内酰胺类的耐药率较高，历年普遍在61.65％以上；对碳青霉烯类抗生素的耐药率呈现明显的上升趋势。广泛耐药鲍曼不动杆菌的耐药情况严重，其中对碳青霉烯类抗生素的耐药率较高，均大于90.11％，对多粘菌素B的耐药率最低，历年均低于1.73％。结论鲍曼不动杆菌和广泛耐药鲍曼不动杆菌在我院五年内的检出率均呈逐年上升趋势，且耐药率逐年增加，临床医生要合理使用抗菌药物，以减少广泛耐药菌株的产生。
目的：瞭解我院2009年-2013年鮑曼不動桿菌的檢齣情況和耐藥變化趨勢，為臨床閤理使用抗菌藥物提供實驗室依據。方法收集我院2009年1月-2013年12月住院患者分離的鮑曼不動桿菌4373株，對其各年檢齣情況和耐藥情況進行分析。結果我院2009年-2013年分彆檢齣鮑曼不動桿菌790株（8.95％）、812株（9.02％）、872株（9.04％）、1025株（11.72％）和874株（11.04％），其中廣汎耐藥鮑曼不動桿菌分彆為364株（46.08％）、402株（49.51％）、446株（51.15％）、565株（55.12％）和579株（66.25％）。4373株鮑曼不動桿菌以痰液標本檢齣率最高（87.50％）；臨床科室分佈以呼吸重癥科（36.57％）、ICU（31.95％）和呼吸內科（7.55％）為主；4373株鮑曼不動桿菌耐藥情況嚴重，對青黴素類、頭孢菌素類、喹諾酮類、磺胺類和單環β-內酰胺類的耐藥率較高，歷年普遍在61.65％以上；對碳青黴烯類抗生素的耐藥率呈現明顯的上升趨勢。廣汎耐藥鮑曼不動桿菌的耐藥情況嚴重，其中對碳青黴烯類抗生素的耐藥率較高，均大于90.11％，對多粘菌素B的耐藥率最低，歷年均低于1.73％。結論鮑曼不動桿菌和廣汎耐藥鮑曼不動桿菌在我院五年內的檢齣率均呈逐年上升趨勢，且耐藥率逐年增加，臨床醫生要閤理使用抗菌藥物，以減少廣汎耐藥菌株的產生。
목적：료해아원2009년-2013년포만불동간균적검출정황화내약변화추세，위림상합리사용항균약물제공실험실의거。방법수집아원2009년1월-2013년12월주원환자분리적포만불동간균4373주，대기각년검출정황화내약정황진행분석。결과아원2009년-2013년분별검출포만불동간균790주（8.95％）、812주（9.02％）、872주（9.04％）、1025주（11.72％）화874주（11.04％），기중엄범내약포만불동간균분별위364주（46.08％）、402주（49.51％）、446주（51.15％）、565주（55.12％）화579주（66.25％）。4373주포만불동간균이담액표본검출솔최고（87.50％）；림상과실분포이호흡중증과（36.57％）、ICU（31.95％）화호흡내과（7.55％）위주；4373주포만불동간균내약정황엄중，대청매소류、두포균소류、규낙동류、광알류화단배β-내선알류적내약솔교고，력년보편재61.65％이상；대탄청매희류항생소적내약솔정현명현적상승추세。엄범내약포만불동간균적내약정황엄중，기중대탄청매희류항생소적내약솔교고，균대우90.11％，대다점균소B적내약솔최저，력년균저우1.73％。결론포만불동간균화엄범내약포만불동간균재아원오년내적검출솔균정축년상승추세，차내약솔축년증가，림상의생요합리사용항균약물，이감소엄범내약균주적산생。
Objective To understand the situation and drug resistant trend of Acinetobacter bauman-nii in our hospital from 2009 to 2013, and to provide laboratory basis for clinical rational use of antimicrobial agents. Methods 4373 strains Acinetobacter baumannii from inpatients were collected in our hospital from January 2009 to December 2013. The situation and drug resistant trend were analyzed in every year. Results The positive rates of Acinetobacter baumannii in our hospital from 2009 to 2013 were 790 strains(8.95%), 812 strains (9.02%), 872 strains (9.04%), 1025 strains (11.72%) and 874 strains (11.04%), respectively. The positive rates of Acinetobacter baumannii with extensive drug resistance were 364 strains (46.08%), 402 strains (49.51%), 446 strains (51.15%), 565 strains (55.12%) and 579 strains (66.25%), respectively. The highest positive rate of 4373 strains Acinetobacter baumannii was sputum specimens (87.50%). The mainly positive rates of Acinetobacter baumannii in clinical departments were respiratory intensive division(36.57%), ICU(31.95%) and respiratory medicine(7.55%). The higher drug resistance rates of 4373 strains Acinetobac-ter baumannii were penicillins, cephalosporins, quinolones, sulfanilamide and single circleβlactams, which were all more than 61.65%. And the drug resistance of Acinetobacter baumannii to carbapenems had rising trend obviously. Acinetobacter baumannii with extensive drug resistance to carbapenems had higher drug resis-tance rate, which were all more than 90.11%. And to polymyxin B had lowest drug resistance rate, which were all less than 1.73%. Conclusion Drug resistant situation of Acinetobacter baumannii is serious, and resistant rate increasing year by year. Doctor should rational use of antimicrobial agents , in order to reduce the occur-rence of extensively drug resistant.
