医学信息
醫學信息
의학신식
Medical Information
2015年
38期
81-81
,共1页
夏艺萍%张蓉辉%柯玉梅%胡伟
夏藝萍%張蓉輝%柯玉梅%鬍偉
하예평%장용휘%가옥매%호위
头颈部肿瘤%放疗%口腔黏膜反应%治疗
頭頸部腫瘤%放療%口腔黏膜反應%治療
두경부종류%방료%구강점막반응%치료
Head and neck tumor%Radiation therapy%Oral mucosa reaction%Treatment
目的观察康复新液雾化吸入对急性放射性口腔黏膜炎的作用。方法将50例头颈部恶性肿瘤患者，随机分为预防用药组和对照组(25例)。预防用药组用康复新液10ml加生理盐水10ml雾化吸入，1次/d，至放疗结束；对照组用生理盐水20ml，4次/d漱口，出现吞咽疼痛时餐前服2%利多卡因15ml。两组患者均采用直线加速器放疗。结果两组急性放射性口腔黏膜炎发生率差异无统计学意义(>0.05)。预防用药组口腔溃疡Ⅰ-Ⅱ级20例，Ⅲ-Ⅳ级1例(4%)；对照组Ⅰ-Ⅱ级15例，Ⅲ-Ⅳ级10例(40%)，对照组中重度口腔溃疡发生率显著高于预防用药组(<0.05)。两组急性黏膜反应出现的时间比较，具有显著性差异(<0.05),表明预防用药组出现黏膜反应较对照组延迟。结论康复新液雾化吸入可降低急性放射性口腔黏膜炎的毒性分级，缓解急性放射性疼痛，延迟急性黏膜反应出现的时间，有助于顺利完成放疗全过程。
目的觀察康複新液霧化吸入對急性放射性口腔黏膜炎的作用。方法將50例頭頸部噁性腫瘤患者，隨機分為預防用藥組和對照組(25例)。預防用藥組用康複新液10ml加生理鹽水10ml霧化吸入，1次/d，至放療結束；對照組用生理鹽水20ml，4次/d漱口，齣現吞嚥疼痛時餐前服2%利多卡因15ml。兩組患者均採用直線加速器放療。結果兩組急性放射性口腔黏膜炎髮生率差異無統計學意義(>0.05)。預防用藥組口腔潰瘍Ⅰ-Ⅱ級20例，Ⅲ-Ⅳ級1例(4%)；對照組Ⅰ-Ⅱ級15例，Ⅲ-Ⅳ級10例(40%)，對照組中重度口腔潰瘍髮生率顯著高于預防用藥組(<0.05)。兩組急性黏膜反應齣現的時間比較，具有顯著性差異(<0.05),錶明預防用藥組齣現黏膜反應較對照組延遲。結論康複新液霧化吸入可降低急性放射性口腔黏膜炎的毒性分級，緩解急性放射性疼痛，延遲急性黏膜反應齣現的時間，有助于順利完成放療全過程。
목적관찰강복신액무화흡입대급성방사성구강점막염적작용。방법장50례두경부악성종류환자，수궤분위예방용약조화대조조(25례)。예방용약조용강복신액10ml가생리염수10ml무화흡입，1차/d，지방료결속；대조조용생리염수20ml，4차/d수구，출현탄인동통시찬전복2%리다잡인15ml。량조환자균채용직선가속기방료。결과량조급성방사성구강점막염발생솔차이무통계학의의(>0.05)。예방용약조구강궤양Ⅰ-Ⅱ급20례，Ⅲ-Ⅳ급1례(4%)；대조조Ⅰ-Ⅱ급15례，Ⅲ-Ⅳ급10례(40%)，대조조중중도구강궤양발생솔현저고우예방용약조(<0.05)。량조급성점막반응출현적시간비교，구유현저성차이(<0.05),표명예방용약조출현점막반응교대조조연지。결론강복신액무화흡입가강저급성방사성구강점막염적독성분급，완해급성방사성동통，연지급성점막반응출현적시간，유조우순리완성방료전과정。
Objective To observe the Kangfuxin liquid atomizing inhalation on acute ef ect of inflammation of radioactive oral mucosa.Methods 50 cases of malignant tumor in head and neck were randomly divided into two groups (25 cases) and the control group (cases). Preventive medication group with Kang Fuxin liquid 10ml add 10ml normal saline and atomization inhalation, 1 times a day, to the end of radiotherapy;the control group with physiological saline 20ml, 4 times daily mouthwash, swal owing pain before the meal service 15ml of 2%lidocaine. Two groups of patients were using linear accelerator radiotherapy.Results There was no significant dif erence in the incidence of acute radiation oral mucosa between the two groups ( >0.05). Prevention of 20 cases of treatment group oral ulcer I~I , II ~IV in 1 case (4%);control group I and I in 15 cases, I I~IV in 10 cases (40%), the control group in severe oral ulcer occur ed was significantly higher than that of preventive medication group ( <0.05). In the two groups, there were significant dif erences in the time of acute mucosal reaction ( <0.05), which indicated that the prevention of the treatment group was delayed in the control group.Conclusion Rehabilitation new atomization inhalation can reduce acute toxicity grading of inflammation of radioactive oral cavity mucous membrane,al eviate the acute radioactive pain,acute mucosa reaction time delay,whole process helps to smooth completion of radiotherapy.
