化工进展
化工進展
화공진전
Chemical Industry and Engineering Progress
2015年
10期
3706-3711,3724
,共7页
孙启梅%王领民%王崇辉%高大成
孫啟梅%王領民%王崇輝%高大成
손계매%왕령민%왕숭휘%고대성
1,3-丙二醇%分离/提取%发酵液
1,3-丙二醇%分離/提取%髮酵液
1,3-병이순%분리/제취%발효액
1,3-propanediol%separation/purification%fermentation broth
1,3-丙二醇是合成聚乳酸的主要原料，以甘油为底物的生物法制备1,3-丙二醇是以绿色化学为特征的技术。但1,3-丙二醇极性很强、微生物发酵液成分较复杂，产品收率偏低，质量难符合制备高性能聚对苯二甲酸丙二醇酯的要求，故1,3-丙二醇的分离提纯成为了生物法合成技术的关键。对于1,3-丙二醇发酵液，提纯过程包括发酵液预处理、脱盐和浓缩提纯。本文讨论了用于1,3-丙二醇提纯的主要技术，包括采用离心、过滤、絮凝脱大分子物质，用离子交换、电渗析、双水相萃取或有机溶剂沉淀等方法脱盐类，及通过精馏、萃取、吸附对发酵液浓缩提纯，或是以上某几个分离工艺的组合。提出整个分离工艺仍存在很多问题，对各工艺路线不断进行优化，开发新的经济高效的分离提取工艺路线，是目前实现规模化生物法生产1,3-丙二醇的技术重点。
1,3-丙二醇是閤成聚乳痠的主要原料，以甘油為底物的生物法製備1,3-丙二醇是以綠色化學為特徵的技術。但1,3-丙二醇極性很彊、微生物髮酵液成分較複雜，產品收率偏低，質量難符閤製備高性能聚對苯二甲痠丙二醇酯的要求，故1,3-丙二醇的分離提純成為瞭生物法閤成技術的關鍵。對于1,3-丙二醇髮酵液，提純過程包括髮酵液預處理、脫鹽和濃縮提純。本文討論瞭用于1,3-丙二醇提純的主要技術，包括採用離心、過濾、絮凝脫大分子物質，用離子交換、電滲析、雙水相萃取或有機溶劑沉澱等方法脫鹽類，及通過精餾、萃取、吸附對髮酵液濃縮提純，或是以上某幾箇分離工藝的組閤。提齣整箇分離工藝仍存在很多問題，對各工藝路線不斷進行優化，開髮新的經濟高效的分離提取工藝路線，是目前實現規模化生物法生產1,3-丙二醇的技術重點。
1,3-병이순시합성취유산적주요원료，이감유위저물적생물법제비1,3-병이순시이록색화학위특정적기술。단1,3-병이순겁성흔강、미생물발효액성분교복잡，산품수솔편저，질량난부합제비고성능취대분이갑산병이순지적요구，고1,3-병이순적분리제순성위료생물법합성기술적관건。대우1,3-병이순발효액，제순과정포괄발효액예처리、탈염화농축제순。본문토론료용우1,3-병이순제순적주요기술，포괄채용리심、과려、서응탈대분자물질，용리자교환、전삼석、쌍수상췌취혹유궤용제침정등방법탈염류，급통과정류、췌취、흡부대발효액농축제순，혹시이상모궤개분리공예적조합。제출정개분리공예잉존재흔다문제，대각공예로선불단진행우화，개발신적경제고효적분리제취공예로선，시목전실현규모화생물법생산1,3-병이순적기술중점。
1,3-propanediol is the main raw material to synthesize PTT. Using glycerol to produce 1,3-propanediol by biological processes is characteristic of green chemistry. Due to the strong polarity of 1,3-propanediol and complex composition of fermentation broth,1,3-propanediol has a low yield and its quality cannot match the requirements for synthesizing high performance PTT. Therefore,the separation and purification of 1,3-propanediol from fermentation broth become the key technology for biosynthesis. There are several steps to realize it,including pretreatment of fermentation broth, desalination,concentration and purification. In this paper,the main methods for separating 1,3-propanediol were discussed. It can be described as the following: centrifugation,filtration and flocculation process can be applied to remove macromolecular substances,and then 1,3-propanediol can be concentrated and purified by icon exchange,electrodialysis,aqueous two-phase extraction,ethanol precipitation to desalt,adopting distillation,extraction and adsorption. It can also be achieved by one or two above processes combined together. There still exist some problems in the whole separation. Each process needs continuously optimized to obtain an economical and efficient separation route. This is the key technology to realize large-scale production of 1,3-propanediol using biological process.
