CAJ | 학술논문

G31P （重组人CXCR1/2拮抗剂）是一种相对分子质量低的蛋白质，能与IL-8竞争结合其受体，导致IL-8与受体的生物学活性丧失，从而阻断中性粒细胞的趋化性及其引起的非特异性免疫应答，从而控制宿主炎症的发展。近年研究发现IL-8和其受体在肿瘤、心血管疾病和炎症反应性疾病，以及旋毛虫病和血吸虫病等疾病中高表达。探讨应用G31P控制炎症发展，以达到防治疾病的目的已成为目前国内外学者研究的热点之一。
G31P （중조인CXCR1/2길항제）시일충상대분자질량저적단백질，능여IL-8경쟁결합기수체，도치IL-8여수체적생물학활성상실，종이조단중성립세포적추화성급기인기적비특이성면역응답，종이공제숙주염증적발전。근년연구발현IL-8화기수체재종류、심혈관질병화염증반응성질병，이급선모충병화혈흡충병등질병중고표체。탐토응용G31P공제염증발전，이체도방치질병적목적이성위목전국내외학자연구적열점지일。
G31P (CXCR1/2 antagonist of human recombinant), a kind of low molecular weight protein, can compete with IL-8 and combine with its receptors, leading to the loss of biological activities of IL-8 and its receptors, blocking the chemotaxis of neutrophils and nonspecific immune response, so as to control the devel-opment of the host inflammation. In recent years, studies found that IL-8 and its receptors were highly ex-pressed in diseases such as cancer, cardiovascular disease and inflammation disease, as well as trichinosis, schistosomiasis. The application of G31P to control inflammation development in order to achieve the purpose of prevention and treatment of disease has become one of hot topics in the study of scholars at home and abroad.