医学信息
醫學信息
의학신식
Medical Information
2015年
37期
350-351
,共2页
血清胱抑素C%域型糖尿病%肾脏损害
血清胱抑素C%域型糖尿病%腎髒損害
혈청광억소C%역형당뇨병%신장손해
Serum Cystatin C%Type 2 Diabetes%Kidney damage
目的：探讨在Ⅱ型糖尿病患者中开展血清胱抑素C(Cys C)检测的价值和意义。方法对95例本院住院的Ⅱ型糖尿病患者采用胶体金颗粒免疫比浊法测定血清胱抑素C(CysC)浓度。同时检测T2DM患者24 h尿微量白蛋白排泄率(UAER),并选择性分成两组,即UAER<30mg/24h组、30mg/24 h<UAER<300mg/24h组,对照组为正常体检者,进行组间比较。结果 T2DM患者尿微量白蛋白组Scr(96.85±24.30)μmol/L,CysC(1.82±0.50)ng/L,与正常对照组比较,差异有统计学意义(<0.05),尿白蛋白正常组、尿微量白蛋白组CysC阳性率分别为30.12%、72.31%。结论血清胱抑素C是一种反映早期糖尿病肾损伤的理想标志物,随肾功能恶化逐渐升高。
目的：探討在Ⅱ型糖尿病患者中開展血清胱抑素C(Cys C)檢測的價值和意義。方法對95例本院住院的Ⅱ型糖尿病患者採用膠體金顆粒免疫比濁法測定血清胱抑素C(CysC)濃度。同時檢測T2DM患者24 h尿微量白蛋白排洩率(UAER),併選擇性分成兩組,即UAER<30mg/24h組、30mg/24 h<UAER<300mg/24h組,對照組為正常體檢者,進行組間比較。結果 T2DM患者尿微量白蛋白組Scr(96.85±24.30)μmol/L,CysC(1.82±0.50)ng/L,與正常對照組比較,差異有統計學意義(<0.05),尿白蛋白正常組、尿微量白蛋白組CysC暘性率分彆為30.12%、72.31%。結論血清胱抑素C是一種反映早期糖尿病腎損傷的理想標誌物,隨腎功能噁化逐漸升高。
목적：탐토재Ⅱ형당뇨병환자중개전혈청광억소C(Cys C)검측적개치화의의。방법대95례본원주원적Ⅱ형당뇨병환자채용효체금과립면역비탁법측정혈청광억소C(CysC)농도。동시검측T2DM환자24 h뇨미량백단백배설솔(UAER),병선택성분성량조,즉UAER<30mg/24h조、30mg/24 h<UAER<300mg/24h조,대조조위정상체검자,진행조간비교。결과 T2DM환자뇨미량백단백조Scr(96.85±24.30)μmol/L,CysC(1.82±0.50)ng/L,여정상대조조비교,차이유통계학의의(<0.05),뇨백단백정상조、뇨미량백단백조CysC양성솔분별위30.12%、72.31%。결론혈청광억소C시일충반영조기당뇨병신손상적이상표지물,수신공능악화축점승고。
Objective To explore the significance of serum Cys C detection in type 2 diabetes.Methods Serum Cys C was determinated in 95 cases of inpatients with type 2 diabetes by using col oidal gold immunoturbidimetry.Meanwhile,the excretion rat of 24h urea micro albumin(UAER)was also detected in the T2DM patients.Al cases were divided into the lower albumin group(UAER<30mg/24h), the higher albumin group (30mg/24 h<UAER<300mg/24h)and normal control group,respectively and analyzed by comparison among groups.Results Serum Scr concentration was 96.85±24.30μmol/L and CysC was 1.82±0.50 ng/L in the higher albumin group of T2DM patients,suggesting that the determinations were significantly dif erent in the higher albumin group compared to the normal control group.The positive rate of CysC was 30.12%、72.31%in the lower albumin group and the higher albumin group,respectively.Conclusion Serum CysC is probably a diagnostic marker at the early kidney injury of diabetes patients and gradual y increased fol owing worse renal dysfunction.
