CAJ | 학술논문

目的：探讨小剂量托吡酯联合奥卡西平治疗小儿癫痫的效果，为提高患儿的疗效提供参考。方法选取我院2011年12月～2014年12月我院收治的70例癫痫患儿，按照简单随机法随机分成观察组和对照组，各35例，分别接受小剂量、正常剂量的托吡酯联合奥卡西平，观察治疗效果。结果与对照组患者相比，观察组的住院时间、治疗时间更短，癫痫发作减少率更少，t=6.342、6.923、9.483，P＜0.05，差异具有统计学意义。对两组患者治疗后疗效进行分析，观察组显效、有效、无效分别为18、14、5例，有效率为91.4%，观察组低于对照组，χ2=8.483，P＜0.05，差异具有统计学意义。结论小剂量托吡酯联合奥卡西平对于小儿癫痫疾病的疗效显著，不良反应少，有助于患儿康复。
목적：탐토소제량탁필지연합오잡서평치료소인전간적효과，위제고환인적료효제공삼고。방법선취아원2011년12월～2014년12월아원수치적70례전간환인，안조간단수궤법수궤분성관찰조화대조조，각35례，분별접수소제량、정상제량적탁필지연합오잡서평，관찰치료효과。결과여대조조환자상비，관찰조적주원시간、치료시간경단，전간발작감소솔경소，t=6.342、6.923、9.483，P＜0.05，차이구유통계학의의。대량조환자치료후료효진행분석，관찰조현효、유효、무효분별위18、14、5례，유효솔위91.4%，관찰조저우대조조，χ2=8.483，P＜0.05，차이구유통계학의의。결론소제량탁필지연합오잡서평대우소인전간질병적료효현저，불량반응소，유조우환인강복。
Objective To explore the small dose of topiramate and oxcarbazepine therapy for the treatment of epilepsy in children, and to provide reference for improving the curative effect of children with. Methods Selected 70 cases of children with epilepsy from December 2011 to December 2014 in our hospital, according to simple random method were randomly divided into the observation group and the control group, each group had 35 cases, respectively adopt small dose, normal dose of topiramate combined with oxcarbazepine, observed the curative effect. Resultscompared with the control group, the observation group time of in hospital, treatment time were shorter and the rate of epileptic seizure was less,t=6.342, 6.923, 9.483,P<0.05, had difference statistically signiifcance. Compared the curative effect of two groups after treatment, the observation group excellent, effect, in vain was 18, 14, 5 cases, the effective rate was 91.4% lower than the control group, χ2=8.483,P<0.05, had difference statistically significance.Conclusion Small dose of topiramate and oxcarbazepine therapy had a significant effect, less adverse reactions for children with epilepsy.