CAJ | 학술논문

8‐异前列腺F2a在体内生成结构稳定，不受食物脂质含量的影响，特异性强，能灵敏地反映体内氧化应激水平并与疾病严重程度相关，是评价氧化应激和脂质过氧化反应的理想生物指标。Ⅱ型肺泡细胞表面抗原6（KL‐6）、肺表面活性蛋白D（SP‐D）主要由肺泡Ⅱ型上皮细胞分泌，夜间慢性间断缺氧及再氧合损伤肺泡屏障、致肺泡部位内皮细胞氧化应激损伤、导致上皮细胞渗透性增高，使KL‐6、SP‐D浓度升高。肥胖是导致OSA HS的重要危险因素，瘦素是一种由脂肪细胞分泌的重要的抗肥胖激素。现对细胞因子8‐异前列腺F2a、KL‐6、SP‐D、瘦素等生物标记物在OSA HS中的关系做一综述。
8‐이전렬선F2a재체내생성결구은정，불수식물지질함량적영향，특이성강，능령민지반영체내양화응격수평병여질병엄중정도상관，시평개양화응격화지질과양화반응적이상생물지표。Ⅱ형폐포세포표면항원6（KL‐6）、폐표면활성단백D（SP‐D）주요유폐포Ⅱ형상피세포분비，야간만성간단결양급재양합손상폐포병장、치폐포부위내피세포양화응격손상、도치상피세포삼투성증고，사KL‐6、SP‐D농도승고。비반시도치OSA HS적중요위험인소，수소시일충유지방세포분비적중요적항비반격소。현대세포인자8‐이전렬선F2a、KL‐6、SP‐D、수소등생물표기물재OSA HS중적관계주일종술。
8‐isoprostane F2a in body can generate a stable structure material which is not affected by dietary lipid content and strong specificity ,can sensitively reflect the oxidative stress levels and is correlated with serious degree of disease ,is the ideal evaluation biological indicators of oxidative stress and lipid peroxidation .KL‐6 and SP‐D are mainly secreted by alveolar type II epithelial cells ,at night ,chronic intermittent hypoxia and reoxygenation injury alveolar barrier ,the oxidative stress injury of endothelial cells in the alveolar region ,resulting in increasing permeability of epithelial cells ,increased the concentration of SP‐D and KL‐6 .Obesity is an important risk factor for OSAHS ,and leptin is an important anti‐obesity hormone secreted by fat cells .In this paper ,the relationship between the biological indicators 8‐isoprostane F2a ,KL‐6 ,SP‐D ,leptin and OSAHS are reviewed .