CAJ | 학술논문

代谢组学（metabonomics）作为继基因组学后新发展起来的一门系统学科，主要研究生物体受外界刺激或扰动后所有低分子量的代谢产物随时空变化的情况，从而探明生物体系代谢途径的一种研究方法。代谢组学近年来发展十分迅速，在植物学、毒理学、临床诊断、药物开发、营养科学等研究领域都取得了大量的成果。本文介绍了近年代谢组学技术在肺炎领域的应用及进展，综述了液相色谱质谱（LC‐MS）及核磁共振谱（NMR）等技术测定肺炎代谢物差异的应用，涉及氨基酸、核酸、能量、胆酸、固醇等五大类代谢机制，并对其发展前景进行了展望。
대사조학（metabonomics）작위계기인조학후신발전기래적일문계통학과，주요연구생물체수외계자격혹우동후소유저분자량적대사산물수시공변화적정황，종이탐명생물체계대사도경적일충연구방법。대사조학근년래발전십분신속，재식물학、독이학、림상진단、약물개발、영양과학등연구영역도취득료대량적성과。본문개소료근년대사조학기술재폐염영역적응용급진전，종술료액상색보질보（LC‐MS）급핵자공진보（NMR）등기술측정폐염대사물차이적응용，섭급안기산、핵산、능량、담산、고순등오대류대사궤제，병대기발전전경진행료전망。
As a new system of disciplinet following genomics ,metabonomics mainly studies the dynamic changes in time and space of all low molecular weight metabolites when biological system is stimulated or disturbed ,which proved a method to research metabolic pathway in biological systems .With rapidly developing in recent years ,metabonomics has made a lot of results in botany ,toxicology ,clinical diagnostics ,drug development ,nutrition science research .As a new genomics research technology , metabonomics greatly enriched the contents of systems biology ,which has become one of the most promising approach in life science research .This review describes the recent metabolomics technology and progress in the field of pneumonia ,and its development prospects .