CAJ | 학술논문

腺苷酸活化蛋白激酶( AMPK)信号通路作为调节细胞能量代谢状态的中心环节,是调控哺乳动物繁殖性能的关键因子。已有研究表明,AMPK在哺乳动物卵巢发育中主要通过介导葡萄糖、胰岛素样生长因子-1( IGF-1)、促卵泡素( FSH)、脂联素等发挥功能。本文就AMPK在哺乳动物卵巢发育中的调控作用及其机制进行综述,旨在引起人们对AMPK调控卵巢发育的关注,并为卵巢疾病的治疗提供一定参考。
선감산활화단백격매( AMPK)신호통로작위조절세포능량대사상태적중심배절,시조공포유동물번식성능적관건인자。이유연구표명,AMPK재포유동물란소발육중주요통과개도포도당、이도소양생장인자-1( IGF-1)、촉란포소( FSH)、지련소등발휘공능。본문취AMPK재포유동물란소발육중적조공작용급기궤제진행종술,지재인기인문대AMPK조공란소발육적관주,병위란소질병적치료제공일정삼고。
Adenosine 5′-monophosphate-activated protein kinase ( AMPK ) regulation pathway is the central part of the cellular energy metabolism, which plays a vital role in the female reproductive tract development. Numerous studies have explored the relationship between AMPK and ovary development, and the role of AMPK mediates glucose, insulin-like growth factor-1 ( IGF-1) , follicle stimulating hormone ( FSH) and adi-ponectin. In this paper, the advances in the regulation of AMPK in the mammalian ovary development were re-viewed in order to promoting further the research on application of AMPK for cure of ovary disease.