CAJ | 학술논문

目的：观察茶碱对支气管哮喘（简称哮喘）患者肺功能及IL‐17、C反应蛋白（CRP）的影响。方法将120例哮喘患者随机分为对照组和治疗组各60例。对照组予以沙美特罗氟替卡松50／250μg每日2次吸入治疗；治疗组在对照组治疗基础上加用茶碱缓释片（0．1g每日2次口服）。2组治疗前均行肺功能及血 IL‐17、CRP检测。4周后复测肺功能及 IL‐17、CRP。结果治疗前2组肺功能及血IL‐17、CRP比较差异无统计学意义（ P ＞0．05）；治疗后肺功能：FEV1％ pred、FEV1／FVC、最大呼气流速％ pred均改善，但2组间改善率比较，差异无统计学意义（ P ＞0．05），用力呼出气量为25％～75％肺活量时的平均流量（FEF25％‐75％）占预计值百分比及 FEF25％‐75％／FVC 明显高于对照组（ P ＜0．01），治疗组血IL‐17、CRP水平下降高于对照组（ P ＜0．01）。结论茶碱能更好的控制哮喘患者的小气道功能及气道炎症，并改善气道高反应性。
목적：관찰다감대지기관효천（간칭효천）환자폐공능급IL‐17、C반응단백（CRP）적영향。방법장120례효천환자수궤분위대조조화치료조각60례。대조조여이사미특라불체잡송50／250μg매일2차흡입치료；치료조재대조조치료기출상가용다감완석편（0．1g매일2차구복）。2조치료전균행폐공능급혈 IL‐17、CRP검측。4주후복측폐공능급 IL‐17、CRP。결과치료전2조폐공능급혈IL‐17、CRP비교차이무통계학의의（ P ＞0．05）；치료후폐공능：FEV1％ pred、FEV1／FVC、최대호기류속％ pred균개선，단2조간개선솔비교，차이무통계학의의（ P ＞0．05），용력호출기량위25％～75％폐활량시적평균류량（FEF25％‐75％）점예계치백분비급 FEF25％‐75％／FVC 명현고우대조조（ P ＜0．01），치료조혈IL‐17、CRP수평하강고우대조조（ P ＜0．01）。결론다감능경호적공제효천환자적소기도공능급기도염증，병개선기도고반응성。
Objective To observe the effect of theophylline on lung function and IL‐17 ,CRP in patients with bronchial asthma (asthma) .Methods One hundred and twenty cases of asthma were randomly divided into control group and treatment group with 60 cases in each group .The control group was given Shah Mette Lo fluticasone 50/250μg 2 times daily inhalation therapy .The treatment group was treated with Theophylline Sustained‐release Tablets on the basis of the control group (Orally 2 times daily 0 .1 g) .The two groups were measured lung function and blood IL‐17 ,CRP before treatment measurement of pulmonary function and IL‐17 ,CRP after 4 weeks .Results There are no significant difference of the two groups of lung function and blood IL‐17 ,CRP before the treatmen ( P >0 .05) .Pulmonary function after treatment :FEV1% pred ,FEV1/FVC ,PEF% pred have improved ,But the two groups had no significant difference between the rate of improvement ( P > 0 .05) ,FEF25%‐75% % in predicted and FEF25%‐75% /FVC were significantly higher than that of control group ( P<0 .01) ,the treatment group blood IL‐17 ,CRP levels decreased than that of the control group ( P <0 .01) .Conclusions Theophylline can better control small airway function and airway inflammation of in asthma patients ,and improve the airway hyperresponsiveness .