中国继续医学教育
中國繼續醫學教育
중국계속의학교육
China Continuing Medical Education
2015年
26期
36-37
,共2页
乳腺浸润性导管癌%EGFR%CK5/6%临床意义
乳腺浸潤性導管癌%EGFR%CK5/6%臨床意義
유선침윤성도관암%EGFR%CK5/6%림상의의
Breast inifltrating ductal carcinoma%EGFR%CK 5/6%Clinical signiifcance
目的：探讨乳腺浸润性导管癌DEFR、CK 5/6的表达情况及其临床应用价值。方法选取我院2013年6月～2014年6月收治的乳腺浸润性导管癌的患者102例作为研究对象，所有患者均经手术病理证实，并有完整的免疫组化法病理检测结果。回顾性分析患者的基本资料、EGFR和CK 5/6表达情况。结果102例乳腺导管浸润癌患者中， EGFR和CK 5/6的阳性表达率分别为27.5%和22.5%，二者的共同表达率为77.5%（79/102），χ2=5.871，P＞0.05，差异不具有统计学意义， EGFR和CK 5/6的表达具有一致性。EGFR和CK 5/6在三阴性乳腺癌中的表达率均高于在非三阴性乳腺癌中的表达率，P＜0.05，差异具有统计学意义。结论通过对乳腺浸润性导管癌DEFR、CK 5/6的表达情况进行分析，可以为患者的病变程度进行判断，为患者的治疗、预后评估提供可靠依据。
目的：探討乳腺浸潤性導管癌DEFR、CK 5/6的錶達情況及其臨床應用價值。方法選取我院2013年6月～2014年6月收治的乳腺浸潤性導管癌的患者102例作為研究對象，所有患者均經手術病理證實，併有完整的免疫組化法病理檢測結果。迴顧性分析患者的基本資料、EGFR和CK 5/6錶達情況。結果102例乳腺導管浸潤癌患者中， EGFR和CK 5/6的暘性錶達率分彆為27.5%和22.5%，二者的共同錶達率為77.5%（79/102），χ2=5.871，P＞0.05，差異不具有統計學意義， EGFR和CK 5/6的錶達具有一緻性。EGFR和CK 5/6在三陰性乳腺癌中的錶達率均高于在非三陰性乳腺癌中的錶達率，P＜0.05，差異具有統計學意義。結論通過對乳腺浸潤性導管癌DEFR、CK 5/6的錶達情況進行分析，可以為患者的病變程度進行判斷，為患者的治療、預後評估提供可靠依據。
목적：탐토유선침윤성도관암DEFR、CK 5/6적표체정황급기림상응용개치。방법선취아원2013년6월～2014년6월수치적유선침윤성도관암적환자102례작위연구대상，소유환자균경수술병리증실，병유완정적면역조화법병리검측결과。회고성분석환자적기본자료、EGFR화CK 5/6표체정황。결과102례유선도관침윤암환자중， EGFR화CK 5/6적양성표체솔분별위27.5%화22.5%，이자적공동표체솔위77.5%（79/102），χ2=5.871，P＞0.05，차이불구유통계학의의， EGFR화CK 5/6적표체구유일치성。EGFR화CK 5/6재삼음성유선암중적표체솔균고우재비삼음성유선암중적표체솔，P＜0.05，차이구유통계학의의。결론통과대유선침윤성도관암DEFR、CK 5/6적표체정황진행분석，가이위환자적병변정도진행판단，위환자적치료、예후평고제공가고의거。
Objective To explore the clinical value of DEFR breast invasive ductal carcinoma, the expression of CK 5/6 cases. Methods Selected 102 cases of patients with infiltrating ductal carcinoma from June 2013 to June 2014 as the research object, all patients were confirmed by surgery pathology, has a full set of immunohistochemical method and pathological results. Patients were retrospectively analyzed, the basic information, EGFR and CK 5/6 expression.Results102 cases of mammary gland carcinoma inifltrating carcinoma patients, EGFR and CK 5/6 positive expression rate of 27.5% and 22.5%, respectively, of the two common expression rate was 77.5% ( 79/102 ), χ2=5.871,P>0.05, had no difference statistically significance, the expression of EGFR and CK 5/6 with consistency. EGFR and CK 5/6 in three negative expression rate of breast cancer were significantly higher than in the three negative expression rate of breast cancer,P<0.05, had difference statistically significance.Conclusion Through the DEFR breast invasive ductal carcinoma, the expression of CK 5/6 cases were analysis, and for the degree of pathological changes in patients with judgment, provide reliable basis for treatment and prognosis evaluation of patients.
