CAJ | 학술논문

最新研究发现了一种新的选择性自噬——脂噬,其可以选择性识别脂质并将其降解,在调节肝细胞脂肪代谢、维持细胞内脂质稳态等过程中发挥重要作用.自噬参与肝细胞的多种功能,不仅可以动员脂滴,调控脂肪的分解代谢,还参与极低密度脂蛋白(VLDL)的分泌和装载.但高脂饮食、饮酒和肝炎病毒会破坏自噬功能,使肝细胞发生脂肪样变、纤维化或凋亡,进一步发展成脂肪肝、酒精肝,甚至肝癌.因而研究脂噬对脂质代谢的调节作用,脂噬对病毒性肝炎和脂肪肝等慢性肝脏疾病的影响很有意义.
최신연구발현료일충신적선택성자서——지서,기가이선택성식별지질병장기강해,재조절간세포지방대사、유지세포내지질은태등과정중발휘중요작용.자서삼여간세포적다충공능,불부가이동원지적,조공지방적분해대사,환삼여겁저밀도지단백(VLDL)적분비화장재.단고지음식、음주화간염병독회파배자서공능,사간세포발생지방양변、섬유화혹조망,진일보발전성지방간、주정간,심지간암.인이연구지서대지질대사적조절작용,지서대병독성간염화지방간등만성간장질병적영향흔유의의.
Current evidence implicates a new type of selective autophagy-lipophagy,which selectively recognizes and breaks down lipids.Lipophagy play essential roles in regulating lipid metabolism and maintaining cellular lipid homeostasis.Autophagy involves in multi-functions in liver.It might not only mobilize lipid droplets to regulate catabolism of lipid but also involves in the secretion and assembly of very low density lipoprotein (VLDL).However,autophagic functions are disordered by high-fat diet,alcohol consumption or hepatitis virus,resulting in steatosis and fibrosis even apoptosis of hepatocytes.These conditions may further lead to the development of fatty liver,alcoholic hepatitis,cirrhosis,and hepatocelluar carcinoma (HCC).It is essential to explore lipophagic regulating roles of lipid metabolism and influences in chromic liver.