CAJ | 학술논문

目的：研究制备氧氟沙星明胶微球的最佳工艺条件。方法以明胶为载体，液体石蜡为油相，Span80为乳化剂，戊二醛为交联剂，采用乳化交联法制备氧氟沙星明胶微球。采用紫外分光光度法测定微球中氧氟沙星的载药量和包封率。考察明胶质量分数、油水相体积比、明胶与氧氟沙星质量比、Span80体积分数对载药量、包封率的影响。以载药量、包封率的总和为评价指标，针对上述4个因素用L9(34)表正交试验设计法进行实验，获得最佳配方比例。结果氧氟沙星明胶微球分别在明胶质量分数20%、油水相体积比为3.5∶1、明胶与氧氟沙星质量比1∶1、Span80体积分数2.5%时，各自载药量、包封率的综合评价指标较高。正交设计证实上述条件下制备工艺最佳。结论本制备工艺稳定可行，氧氟沙星明胶微球的载药量和包封率可达到约80％。
목적：연구제비양불사성명효미구적최가공예조건。방법이명효위재체，액체석사위유상，Span80위유화제，무이철위교련제，채용유화교련법제비양불사성명효미구。채용자외분광광도법측정미구중양불사성적재약량화포봉솔。고찰명효질량분수、유수상체적비、명효여양불사성질량비、Span80체적분수대재약량、포봉솔적영향。이재약량、포봉솔적총화위평개지표，침대상술4개인소용L9(34)표정교시험설계법진행실험，획득최가배방비례。결과양불사성명효미구분별재명효질량분수20%、유수상체적비위3.5∶1、명효여양불사성질량비1∶1、Span80체적분수2.5%시，각자재약량、포봉솔적종합평개지표교고。정교설계증실상술조건하제비공예최가。결론본제비공예은정가행，양불사성명효미구적재약량화포봉솔가체도약80％。
Objective To study the optimum condition of preparing ofloxaxcin gelatin microspheres. Methods Oflox?axcin gelatin microspheres were manufactured using the emulsion chemical-cross linking method and gelatin was employed as carrier, liquid paraffin as oil phase, Span80 as emulsifier, . The loading capability and entrapment efficiency of the ofloxax?cin gelatin microspheres were determined by UV Spectrophotometry. The effect of gelatin concentration, oil/water volume ra?tio, gelatin/ofloxaxcin mass ratio and volume fraction of span80 on drug loading capability and entrapment efficiency were in?vestigated. The optimum proportions of each component was obtained by L9 (34) orthogonal test, based on the above 4 factors, using sum of drug loading capability and entrapment efficiency as evaluation index. Results The optimum condition for manufacturing high quality ofloxaxcin gelatin microspheres used 20%of gelatin concentration,water/oil volume ratio at 3.5∶1, gelatin/ofloxaxcin mass ratio at 1∶1, the span 80 volume fraction of 2.5%. Conclusion Drug loading capability and entrap?ment efficiency of the ofloxaxcin gelatin microspheres reached 80%using this manufacture technology therefore the prepara?tion was stable and feasible.