实用检验医师杂志
實用檢驗醫師雜誌
실용검험의사잡지
Chinese Journal of Laboratory Pathologist
2015年
3期
173-176
,共4页
翟凯齐%张丽娜%高巍%张汉涛
翟凱齊%張麗娜%高巍%張漢濤
적개제%장려나%고외%장한도
S100β蛋白%神经元特异性烯醇化酶%手足口病%联合检测
S100β蛋白%神經元特異性烯醇化酶%手足口病%聯閤檢測
S100β단백%신경원특이성희순화매%수족구병%연합검측
S100βprotein%Neuron-specific enolase%Hand-foot-mouth disease%Joint detection
目的：探讨S100β蛋白及神经元特异性烯醇化酶（neuron-specific enolase， NSE）联合检测在手足口病（hand-foot-and-mouth disease， HFMD）诊疗中的临床应用价值。方法收集2014年10月至2015年2月我院收治的318例HFMD患儿，根据临床表现分为轻症组157例、重症组104例、危重症组57例，同期选择100例健康体检儿童为健康对照组，检测受试儿童血清S100β蛋白及NSE水平，重症组及危重症组患儿于治疗1w后复检，对检测结果进行统计学分析。结果健康对照组及HFMD各组间血清S100β蛋白及NSE检测结果差异均有统计学意义（F＝7.91，F＝6.37，P均＝0.010）。HFMD各组血清S100β蛋白及NSE检测结果均高于健康对照组，且差异均有统计学意义（P均＜0.05）；且随着病情严重程度的增加，血清S100β蛋白及NSE检测结果均逐渐升高，各组间两两比较，差异均有统计学意义（P均＜0.05）。重症组HFMD患儿治疗后血清S100β蛋白及NSE检测结果均低于治疗前，且差异均有统计学意义（t＝12.35，t＝9.71，P均＜0.05）；危重症组HFMD患儿治疗前后血清S100β蛋白及NSE检测结果差异均无统计学意义（t＝0.23，t＝0.21，P均＞0.05）。结论血清S100β蛋白及NSE水平的检测可用于HFMD患儿合并脑损伤的早期诊断、病情判断、治疗效果及预后评估。
目的：探討S100β蛋白及神經元特異性烯醇化酶（neuron-specific enolase， NSE）聯閤檢測在手足口病（hand-foot-and-mouth disease， HFMD）診療中的臨床應用價值。方法收集2014年10月至2015年2月我院收治的318例HFMD患兒，根據臨床錶現分為輕癥組157例、重癥組104例、危重癥組57例，同期選擇100例健康體檢兒童為健康對照組，檢測受試兒童血清S100β蛋白及NSE水平，重癥組及危重癥組患兒于治療1w後複檢，對檢測結果進行統計學分析。結果健康對照組及HFMD各組間血清S100β蛋白及NSE檢測結果差異均有統計學意義（F＝7.91，F＝6.37，P均＝0.010）。HFMD各組血清S100β蛋白及NSE檢測結果均高于健康對照組，且差異均有統計學意義（P均＜0.05）；且隨著病情嚴重程度的增加，血清S100β蛋白及NSE檢測結果均逐漸升高，各組間兩兩比較，差異均有統計學意義（P均＜0.05）。重癥組HFMD患兒治療後血清S100β蛋白及NSE檢測結果均低于治療前，且差異均有統計學意義（t＝12.35，t＝9.71，P均＜0.05）；危重癥組HFMD患兒治療前後血清S100β蛋白及NSE檢測結果差異均無統計學意義（t＝0.23，t＝0.21，P均＞0.05）。結論血清S100β蛋白及NSE水平的檢測可用于HFMD患兒閤併腦損傷的早期診斷、病情判斷、治療效果及預後評估。
목적：탐토S100β단백급신경원특이성희순화매（neuron-specific enolase， NSE）연합검측재수족구병（hand-foot-and-mouth disease， HFMD）진료중적림상응용개치。방법수집2014년10월지2015년2월아원수치적318례HFMD환인，근거림상표현분위경증조157례、중증조104례、위중증조57례，동기선택100례건강체검인동위건강대조조，검측수시인동혈청S100β단백급NSE수평，중증조급위중증조환인우치료1w후복검，대검측결과진행통계학분석。결과건강대조조급HFMD각조간혈청S100β단백급NSE검측결과차이균유통계학의의（F＝7.91，F＝6.37，P균＝0.010）。HFMD각조혈청S100β단백급NSE검측결과균고우건강대조조，차차이균유통계학의의（P균＜0.05）；차수착병정엄중정도적증가，혈청S100β단백급NSE검측결과균축점승고，각조간량량비교，차이균유통계학의의（P균＜0.05）。중증조HFMD환인치료후혈청S100β단백급NSE검측결과균저우치료전，차차이균유통계학의의（t＝12.35，t＝9.71，P균＜0.05）；위중증조HFMD환인치료전후혈청S100β단백급NSE검측결과차이균무통계학의의（t＝0.23，t＝0.21，P균＞0.05）。결론혈청S100β단백급NSE수평적검측가용우HFMD환인합병뇌손상적조기진단、병정판단、치료효과급예후평고。
Objective To study the clinical application value of S100βserum protein and serum neu-ron-specific enolase (NSE) joint detection in the diagnosis of children with hand-foot-and-mouth disease (HFMD) combine brain injuries. Methods 318 cases of children with HFMD from October 2014 to February 2015 in our hospital were collected, and they were divided into mild group (157 cases), severe group (104 cases) and critical illness group (57 cases) according to the clinical manifestations. 100 cases of healthy chil-dren were selected as the control group. The S100βprotein and NSE levels of all the children were detected , and the results were analyzed statistically. Results There were statistical significance in the differences of S100βprotein and NSE levels among HFMD each groups and control group (F=7.91, F=6.37, Pall=0.010). The S100βprotein and NSE levels in HFMD each groups were all higher than that of control group , and the differences all had statistical significance(Pall<0.05). The S100βprotein and NSE levels increased along with the severity of patient's condition, and the differences all had statistical significance between each two HFMD groups (Pall<0.05). The S100βprotein and NSE levels of severe group in post treatment were all lower than that of before treatment, and the differences all had statistical significance (t=12.35, t=9.71, Pall<0.05). There were no statistical significance in the differences of S100βprotein and NSE levels of critical illness group between before and post treatment(t=0.23, t=0.21, Pall>0.05). Conclusion The detection of serum S100βprotein and NSE can be used for the early diagnosis, condition judgment, and the evaluation of treatment effect and prognosis of HFMD combine brain injuries.
