国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
International Journal of Immunology
2015年
5期
465-469
,共5页
寄生虫%类风湿关节炎%树突状细胞%辅助T细胞%调节性T细胞
寄生蟲%類風濕關節炎%樹突狀細胞%輔助T細胞%調節性T細胞
기생충%류풍습관절염%수돌상세포%보조T세포%조절성T세포
Parasite%Rheumatoid arthritis%Dendritic cells%Helper T cell%Regulatory T cell
近些年随着对类风湿关节炎(RA)诊治水平的进步,特别是生物制剂的应用明显改善了RA患者的预后.但是在治疗的同时会有副作用,尤其是感染的风险,所以有必要不断探索新的治疗方式,寄生虫疗法就是其中之一.大量的动物实验和临床研究证实了以寄生虫为基础的治疗方法在RA中有治疗潜力.通过研究寄生虫对机体的免疫调节作用以及诱导免疫耐受的机制,进一步探索这种生物治疗调节免疫系统的方式.这将有助于创造治疗RA的新型药物.
近些年隨著對類風濕關節炎(RA)診治水平的進步,特彆是生物製劑的應用明顯改善瞭RA患者的預後.但是在治療的同時會有副作用,尤其是感染的風險,所以有必要不斷探索新的治療方式,寄生蟲療法就是其中之一.大量的動物實驗和臨床研究證實瞭以寄生蟲為基礎的治療方法在RA中有治療潛力.通過研究寄生蟲對機體的免疫調節作用以及誘導免疫耐受的機製,進一步探索這種生物治療調節免疫繫統的方式.這將有助于創造治療RA的新型藥物.
근사년수착대류풍습관절염(RA)진치수평적진보,특별시생물제제적응용명현개선료RA환자적예후.단시재치료적동시회유부작용,우기시감염적풍험,소이유필요불단탐색신적치료방식,기생충요법취시기중지일.대량적동물실험화림상연구증실료이기생충위기출적치료방법재RA중유치료잠력.통과연구기생충대궤체적면역조절작용이급유도면역내수적궤제,진일보탐색저충생물치료조절면역계통적방식.저장유조우창조치료RA적신형약물.
Along with the progress of the diagnosis and treatment of rheumatoid arthritis (RA),especially with the application of biological agents,the prognosis of RA patients has obviously been improved in recent years.However,at the same time,patients have to face corresponding adverse effects,especially the increasing risk of infection.Therefore,it is necessary to explore new ways of treatment-parasite therapy is one of them.A large number of animal experiments and clinical studies have confirmed the parasite's potential in the treatment of RA.By studying the immunomodulatory effects of parasite and the induction of immune tolerance mechanism,we can explore the way by which this biological treatment adjusts the immune system.These studies will be helpful to create new drugs for the treatment of RA.
