CAJ | 학술논문

胃癌是全球最常见的恶性肿瘤之一，影响胃癌预后的因素较多，患者的肿瘤局部免疫反应就是其中之一。近年来肿瘤浸润淋巴细胞成为胃癌预后的热点研究。本文介绍了胃癌肿瘤浸润淋巴细胞的亚型、临床分型及与患者预后关系的研究进展，认为胃癌内的调节性T细胞（ Treg）通常与不利的预后相关，而肿瘤浸润的CD8＋细胞毒性T细胞、 CD45 RO记忆T细胞、 B淋巴细胞和淋巴小结通常与良好的胃癌预后相关，为进一步研究胃癌患者肿瘤局部免疫反应的关键机制和临床治疗提供了一定依据。
위암시전구최상견적악성종류지일，영향위암예후적인소교다，환자적종류국부면역반응취시기중지일。근년래종류침윤림파세포성위위암예후적열점연구。본문개소료위암종류침윤림파세포적아형、림상분형급여환자예후관계적연구진전，인위위암내적조절성T세포（ Treg）통상여불리적예후상관，이종류침윤적CD8＋세포독성T세포、 CD45 RO기억T세포、 B림파세포화림파소결통상여량호적위암예후상관，위진일보연구위암환자종류국부면역반응적관건궤제화림상치료제공료일정의거。
Gastric cancer is one of the most common malignant tumors in the world.The influencing factors for gastric carcinoma are numerous , among which tumor local immune response is one of the influencing factors.In recent years , tumor infiltrating lymphocytes became a hot issue in the research of gastric cancer prognosis.In this paper , we introduced the subtypes and clinical classification of tumor infiltrating lymphocytes of gastric cancer.And we found that Treg in gastric carcinoma is normally associated with unfavorable prognosis , and tumor-infiltrating CD8 +CTLs, CD45 RO memory T cells, B lymphocyte and lymph nodules are normally associated with favorable prognosis of gastric carcinoma.The findings may provide a reference for the further research of the key mechanism of tumor local immune response in patients with gastric cancer and clinical treatment .