内蒙古民族大学学报（自然科学版）
內矇古民族大學學報（自然科學版）
내몽고민족대학학보（자연과학판）
Journal of Inner Mongolia University for Nationalities (Natural Sciences)
2015年
5期
424-427
,共4页
益肾散%保肾散%抗炎%急性毒性
益腎散%保腎散%抗炎%急性毒性
익신산%보신산%항염%급성독성
Yishen powder%Baoshen powder%Anti-inflammatory%Acute toxicity
目的：研究蒙药益肾散和保肾散联合用药的的抗炎作用及其急性毒性.方法：采用二甲苯致小鼠耳廓肿胀及鸡蛋清致大鼠足肿胀的方法，观察其抗炎作用；对益肾散和保肾散进行最大耐受量试验.结果：益肾散和保肾散联合用药中、高剂量均能明显减轻二甲苯致小鼠耳廓肿胀（P<0.05）.低剂量能显著减少致炎后0.5h，1h，2h大鼠足肿胀（P<0.05），中剂量能显著减少致炎后0.5h，1h，2h，4h，6h大鼠足肿胀（P<0.05，P<0.01），高剂量能显著减少致炎后0.5h，1h大鼠足肿胀（P<0.05）.益肾散最大耐受量是成人临床用量的288倍，保肾散为369倍.结论：益肾散和保肾散联合用药具有抗炎作用，该两种药均无急性毒性.
目的：研究矇藥益腎散和保腎散聯閤用藥的的抗炎作用及其急性毒性.方法：採用二甲苯緻小鼠耳廓腫脹及鷄蛋清緻大鼠足腫脹的方法，觀察其抗炎作用；對益腎散和保腎散進行最大耐受量試驗.結果：益腎散和保腎散聯閤用藥中、高劑量均能明顯減輕二甲苯緻小鼠耳廓腫脹（P<0.05）.低劑量能顯著減少緻炎後0.5h，1h，2h大鼠足腫脹（P<0.05），中劑量能顯著減少緻炎後0.5h，1h，2h，4h，6h大鼠足腫脹（P<0.05，P<0.01），高劑量能顯著減少緻炎後0.5h，1h大鼠足腫脹（P<0.05）.益腎散最大耐受量是成人臨床用量的288倍，保腎散為369倍.結論：益腎散和保腎散聯閤用藥具有抗炎作用，該兩種藥均無急性毒性.
목적：연구몽약익신산화보신산연합용약적적항염작용급기급성독성.방법：채용이갑분치소서이곽종창급계단청치대서족종창적방법，관찰기항염작용；대익신산화보신산진행최대내수량시험.결과：익신산화보신산연합용약중、고제량균능명현감경이갑분치소서이곽종창（P<0.05）.저제량능현저감소치염후0.5h，1h，2h대서족종창（P<0.05），중제량능현저감소치염후0.5h，1h，2h，4h，6h대서족종창（P<0.05，P<0.01），고제량능현저감소치염후0.5h，1h대서족종창（P<0.05）.익신산최대내수량시성인림상용량적288배，보신산위369배.결론：익신산화보신산연합용약구유항염작용，해량충약균무급성독성.
Objective:To study the anti-inflammatory effect and acute toxicity of combination of Yishen powder(Y) and Baoshen powder(B). Methods:The mouse auricle swelling was induced by xylene and the rat foot swelling was induced by egg-white, they were orally given Y combined with B, the anti-inflammation effects of the two drugs were observed, and the acute toxicity of the two drugs were checked by the maximal tolerance dose test. Results:The me-dium dose and high dose of Y and B could significantly reduce xylene-induced mouse auricle swelling;low-dose of Y and B could significantly reduce rat foot swelling after egg white-induced inflammation 0.5h, 1h, 2h(P<0.05), the medium dose could significantly reduce rats foot swelling after inflammation 0.5h, 1h, 2h, 4h, 6h(P<0.05, P<0.01), the high doses could significantly reduce rats foot swelling after inflammation 0.5h, 1h(P<0.05). The maxi-mal tolerance dose of Y was 288 times of clinical adult dosage, of B was 369 times of clinical adult dosage. Conclu-sion:Combination of Y and B has a significant anti-inflammatory effect and has no significant acute toxicity.
