临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
Chinese Journal of Clinical Rational Drug Use
2015年
29期
11-12
,共2页
肾小球肾炎,慢性%氯沙坦钾片%脉络宁注射液
腎小毬腎炎,慢性%氯沙坦鉀片%脈絡寧註射液
신소구신염,만성%록사탄갑편%맥락저주사액
Chronic glomerulonephritis%Losartan potassium%MaiLuoNing injection
目的：探讨氯沙坦钾联合脉络宁注射液治疗慢性肾小球肾炎的临床治疗效果及安全性。方法选择2012年1月-2013年12月医院收治的慢性肾小球肾炎患者121例，随机分为治疗组61例和对照组60例。2组均予常规治疗，同时对照组予氯沙坦钾片口服；治疗组在对照组治疗基础上加用脉络宁注射液治疗。2个月为1个疗程治疗，连续治疗2个疗程，观察、比较2组疗效及治疗前后血肌酐，24h尿蛋白、血尿素氮指标。结果治疗组总有效率为86.89%明显高于对照组的70.00%，比较差异有统计学意义（ P<0.05）；2组治疗后肌酐、24h尿蛋白、尿素氮与治疗前比较均下降，且治疗组较对照组下降更明显，治疗组不良反应发生率亦低于对照组，差异有统计学意义（P<0.05）。结论氯沙坦钾联合脉络宁注射液治疗慢性肾小球肾炎，临床效果显著，安全性高，不良反应少，值得推广应用。
目的：探討氯沙坦鉀聯閤脈絡寧註射液治療慢性腎小毬腎炎的臨床治療效果及安全性。方法選擇2012年1月-2013年12月醫院收治的慢性腎小毬腎炎患者121例，隨機分為治療組61例和對照組60例。2組均予常規治療，同時對照組予氯沙坦鉀片口服；治療組在對照組治療基礎上加用脈絡寧註射液治療。2箇月為1箇療程治療，連續治療2箇療程，觀察、比較2組療效及治療前後血肌酐，24h尿蛋白、血尿素氮指標。結果治療組總有效率為86.89%明顯高于對照組的70.00%，比較差異有統計學意義（ P<0.05）；2組治療後肌酐、24h尿蛋白、尿素氮與治療前比較均下降，且治療組較對照組下降更明顯，治療組不良反應髮生率亦低于對照組，差異有統計學意義（P<0.05）。結論氯沙坦鉀聯閤脈絡寧註射液治療慢性腎小毬腎炎，臨床效果顯著，安全性高，不良反應少，值得推廣應用。
목적：탐토록사탄갑연합맥락저주사액치료만성신소구신염적림상치료효과급안전성。방법선택2012년1월-2013년12월의원수치적만성신소구신염환자121례，수궤분위치료조61례화대조조60례。2조균여상규치료，동시대조조여록사탄갑편구복；치료조재대조조치료기출상가용맥락저주사액치료。2개월위1개료정치료，련속치료2개료정，관찰、비교2조료효급치료전후혈기항，24h뇨단백、혈뇨소담지표。결과치료조총유효솔위86.89%명현고우대조조적70.00%，비교차이유통계학의의（ P<0.05）；2조치료후기항、24h뇨단백、뇨소담여치료전비교균하강，차치료조교대조조하강경명현，치료조불량반응발생솔역저우대조조，차이유통계학의의（P<0.05）。결론록사탄갑연합맥락저주사액치료만성신소구신염，림상효과현저，안전성고，불량반응소，치득추엄응용。
Objective To investigate the effect and safety of losartan potassium combined with MaiLuoNing injection in the treatment of chronic glomerulonephritis. Methods 121 cases of patients with chronic glomerulonephritis were randomly divided into treatment group(61 cases and control group(60 cases). 2 groups were treated with conventional therapy,and the control group given chlorine potassium. The treatment group was treated with MaiLuoNing injection on the basis of the control group. 2 months for 1 courses of treatment,continuous treatment of 2 courses. The treatment effect,Scr,Pro 24h and BUN be-fore and after treatment of 2 groups were compared. Results The total effective rate of the treatment group was 70%,which was significantly higher than that of the control group(P<0. 05);After treatment,The 24h Pro,BUN and Scr in the 2 groups were decreased,and the treatment group was significantly decreased compared with the control group,and the incidence of ad-verse reactions in the treatment group was lower than that in the control group,the difference was statistically significant( P<0. 05). Conclusion The clinical efficacy of losartan potassium combined with MaiLuoNing injection in treating chronic glo-merulonephritis is very good. high safety,less adverse reactions,worthy of clinical popularization and application.
