CAJ | 학술논문

目的：了解盐酸羟考酮控释片联合氟哌噻吨美利曲辛片对恶性肿瘤患者的治疗效果。方法选取2010年1月—2013年12月在广东医学院附属惠东医院接受住院治疗的恶性肿瘤患者80例。根据治疗方法，将其分为联合治疗组（n＝41）和对照组（n＝39）。对照组患者采用盐酸羟考酮控释片治疗，联合治疗组采用盐酸羟考酮控释片与氟哌噻吨美利曲辛片联合治疗，治疗时间均为10 d。记录并比较两组疼痛缓解效果、盐酸羟考酮控释片维持剂量、不良反应发生率，以及治疗前后的数字评价量表（ NRS）评分、抑郁和焦虑发生率。结果（1）两组疼痛缓解效果比较，差异无统计学意义（P＞0.05）。（2）两组盐酸羟考酮控释片维持剂量比较，差异无统计学意义（P＞0.05）。（3）治疗前后，两组间NRS评分比较，差异均无统计学意义（ P＞0.05）；治疗后，两组NRS评分与治疗前比较，差异均有统计学意义（P＜0.05）。（4）治疗前，两组抑郁发生率比较，差异无统计学意义（P＞0.05）；治疗后，两组抑郁发生率比较，差异有统计学意义（P＜0.05）。治疗后，对照组抑郁发生率与治疗前比较，差异无统计学意义（P＞0.05）；而联合治疗组与治疗前比较，差异有统计学意义（P＜0.05）。（5）治疗前后，两组焦虑发生率比较，差异均无统计学意义（P＞0.05）。治疗后，对照组焦虑发生率与治疗前比较，差异无统计学意义（P＞0.05）；而联合治疗组与治疗前比较，差异有统计学意义（P＜0.05）。（6）两组便秘发生率比较，差异有统计学意义（P＜0.05）。结论盐酸羟考酮控释片联合氟哌噻吨美利曲辛片既能有效缓解恶性肿瘤患者的疼痛程度，又能改善其抑郁和焦虑情绪，且不良反应较少。
목적：료해염산간고동공석편연합불고새둔미리곡신편대악성종류환자적치료효과。방법선취2010년1월—2013년12월재엄동의학원부속혜동의원접수주원치료적악성종류환자80례。근거치료방법，장기분위연합치료조（n＝41）화대조조（n＝39）。대조조환자채용염산간고동공석편치료，연합치료조채용염산간고동공석편여불고새둔미리곡신편연합치료，치료시간균위10 d。기록병비교량조동통완해효과、염산간고동공석편유지제량、불량반응발생솔，이급치료전후적수자평개량표（ NRS）평분、억욱화초필발생솔。결과（1）량조동통완해효과비교，차이무통계학의의（P＞0.05）。（2）량조염산간고동공석편유지제량비교，차이무통계학의의（P＞0.05）。（3）치료전후，량조간NRS평분비교，차이균무통계학의의（ P＞0.05）；치료후，량조NRS평분여치료전비교，차이균유통계학의의（P＜0.05）。（4）치료전，량조억욱발생솔비교，차이무통계학의의（P＞0.05）；치료후，량조억욱발생솔비교，차이유통계학의의（P＜0.05）。치료후，대조조억욱발생솔여치료전비교，차이무통계학의의（P＞0.05）；이연합치료조여치료전비교，차이유통계학의의（P＜0.05）。（5）치료전후，량조초필발생솔비교，차이균무통계학의의（P＞0.05）。치료후，대조조초필발생솔여치료전비교，차이무통계학의의（P＞0.05）；이연합치료조여치료전비교，차이유통계학의의（P＜0.05）。（6）량조편비발생솔비교，차이유통계학의의（P＜0.05）。결론염산간고동공석편연합불고새둔미리곡신편기능유효완해악성종류환자적동통정도，우능개선기억욱화초필정서，차불량반응교소。
Objective To observe the effect of oxycodone hydrochloride controlled release tablets combined with flupentixol and melitracen tablets on the treatment of patients with malignant tumor.Methods We enrolled 80 patients with malignant tumor who were admitted into the Affiliated Huidong Hospital of Guangdong Medical College from January 2010 to December 2013.According to treatment methods , the subjects were divided into two groups: combined treatment group ( n=41) and control group (n=39) .The control group was administrated with oxycodone hydrochloride controlled release tablets , and the combined treatment group was treated by oxycodone hydrochloride controlled release tablets combined with flupentixol and melitracen tablets.The treatment duration was 10 days for both groups.Record and comparison was made between the two groups in pain-relieving effect , the maintenance dose of oxycodone hydrochloride controlled release tablets , adverse reaction during treatment, NRS score before and after treatment, prevalence of depressive and prevalence of anxiety.Results (1) The two groups were not significantly different in pain -relieving effect (P>0.05) .(2) The two groups were not significantly different in the maintenance dose of oxycodone hydrochloride controlled release tablets (P>0.05) .(3) Before and after treatment, the two groups were not significantly different in NRS score ( P>0.05 ); after the treatment , the two groups had lower NRS score than that before treatment (P<0.05) .(4) Before treatment, the two groups were not significantly different in the prevalence of depression ( P>0.05 ); after treatment , the two groups were significantly different in the prevalence of depression ( P<0.05) .After treatment, the prevalence of depression of control group was not significantly different from that after treatment (P>0.05), while the prevalence of depression of combined treatment group was significantly different from that before treatment (P<0.05) .(5) Before and after treatment, the two groups were not significantly different in the prevalence of anxiety (P>0.05) .After treatment, the prevalence rate of anxiety of control group was not significantly different from that before treatment ( P>0.05 ) , while the prevalence rate of anxiety of combined treatment group was significantly different from that before treatment ( P<0.05 ) .( 6 ) The two groups were not significantly different in the prevalence of constipation ( P <0.05 ) . Conclusion The combined application of oxycodone hydrochloride controlled release tablets and flupentixol and melitracen tablets could effectively relieve the pain in patients with malignant tumor , ease depression and negative emotions and reduce adverse reaction.