现代中西医结合杂志
現代中西醫結閤雜誌
현대중서의결합잡지
Modern Journal of Integrated Traditional Chinese and Western Medicine
2015年
29期
3207-3209,3306
,共4页
复元醒脑汤%腔隙性脑梗死%白细胞介素-6%肿瘤坏死因子-α%一氧化氮
複元醒腦湯%腔隙性腦梗死%白細胞介素-6%腫瘤壞死因子-α%一氧化氮
복원성뇌탕%강극성뇌경사%백세포개소-6%종류배사인자-α%일양화담
Fuyuanxingnao Decoction%lacunar infarction%interleukin-6%tumor necrosis factor -α%nitric oxide
目的 探讨复元醒脑汤联合西药治疗腔隙性脑梗死的疗效及其对血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和一氧化氮(NO)水平的影响. 方法 将腔隙性脑梗死患者90例随机分为观察组和对照组,每组45例. 对照组予以常规药物治疗,观察组在对照组的基础上予以复元醒脑汤治疗. 观察2组临床疗效及治疗前后美国国立卫生院神经功能缺损评分(NIHSS)、Barthel指数评定量表(BI)评分、颈动脉内-中膜厚度(IMT)、IL-6、TNF-α和NO水平变化. 结果 观察组总有效率明显高于对照组( P<0 .05 );2组治疗后NIHSS、IMT及血清IL-6、TNF-α和NO水平均较治疗前明显降低(P均<0.05),BI评分较治疗前明显升高(P<0.05),且观察组降低或者升高更为明显(P均<0.05). 结论 复元醒脑汤联合西药治疗腔隙性脑梗死的疗效显著,能够减轻神经功能损伤,提高日常生活能力,其机制可能与抑制机体炎症递质的释放有关.
目的 探討複元醒腦湯聯閤西藥治療腔隙性腦梗死的療效及其對血清白細胞介素-6(IL-6)、腫瘤壞死因子-α(TNF-α)和一氧化氮(NO)水平的影響. 方法 將腔隙性腦梗死患者90例隨機分為觀察組和對照組,每組45例. 對照組予以常規藥物治療,觀察組在對照組的基礎上予以複元醒腦湯治療. 觀察2組臨床療效及治療前後美國國立衛生院神經功能缺損評分(NIHSS)、Barthel指數評定量錶(BI)評分、頸動脈內-中膜厚度(IMT)、IL-6、TNF-α和NO水平變化. 結果 觀察組總有效率明顯高于對照組( P<0 .05 );2組治療後NIHSS、IMT及血清IL-6、TNF-α和NO水平均較治療前明顯降低(P均<0.05),BI評分較治療前明顯升高(P<0.05),且觀察組降低或者升高更為明顯(P均<0.05). 結論 複元醒腦湯聯閤西藥治療腔隙性腦梗死的療效顯著,能夠減輕神經功能損傷,提高日常生活能力,其機製可能與抑製機體炎癥遞質的釋放有關.
목적 탐토복원성뇌탕연합서약치료강극성뇌경사적료효급기대혈청백세포개소-6(IL-6)、종류배사인자-α(TNF-α)화일양화담(NO)수평적영향. 방법 장강극성뇌경사환자90례수궤분위관찰조화대조조,매조45례. 대조조여이상규약물치료,관찰조재대조조적기출상여이복원성뇌탕치료. 관찰2조림상료효급치료전후미국국립위생원신경공능결손평분(NIHSS)、Barthel지수평정량표(BI)평분、경동맥내-중막후도(IMT)、IL-6、TNF-α화NO수평변화. 결과 관찰조총유효솔명현고우대조조( P<0 .05 );2조치료후NIHSS、IMT급혈청IL-6、TNF-α화NO수평균교치료전명현강저(P균<0.05),BI평분교치료전명현승고(P<0.05),차관찰조강저혹자승고경위명현(P균<0.05). 결론 복원성뇌탕연합서약치료강극성뇌경사적료효현저,능구감경신경공능손상,제고일상생활능력,기궤제가능여억제궤체염증체질적석방유관.
Objective It is to observe the effect of Fuyuanxingnao Decoction combined with western medicine in patients with lacunar infarction and their impact on the levels of interleukin -6 ( IL-6) , tumor necrosis factor -α( TNF-α) and nitric oxide ( NO ) .Methods 90 patients with lacunar infarction were randomly divided into observation group and control group, each group had 45 cases.Control group received conventional drug treatment, observation group were treated with Fuyuanxingnao Decoction in the basis of the control group.Efficacy after treatment were observed in each group, the US Na-tional Institutes of Health neurological deficits ( NIHSS) , Barthel Index Rating Scale ( BI) score, carotid intima-media thick-ness (IMT), IL-6, TNF-αand NO levels were also detected before and after treatment in both groups.Results The total effective rate in observation group was significantly higher than that in control group (P<0.05).After treatment the levels of NIHSS, IMT, IL-6, TNF-αand NO were significantly lower, while the levels of BI was significantly higher than those be-fore treatment in both groups(P<0.05), the changes were more obvious in observation group (P<0.05).Conclusion Fuyuanxingnao Decoction combined with western medicine had a good effect on lacunar infarction, it can reduce neurological damage and improve function in daily life, its mechanism may be related to inhibit the body's release of inflammatory media-tors.
