空军医学杂志
空軍醫學雜誌
공군의학잡지
Medical Journal of Air Force
2015年
3期
172-174,177
,共4页
程吉%李京京%张思鑫%张俊伟%李占建
程吉%李京京%張思鑫%張俊偉%李佔建
정길%리경경%장사흠%장준위%리점건
改良超滤%体外循环%心脏手术%低体质量%成人
改良超濾%體外循環%心髒手術%低體質量%成人
개량초려%체외순배%심장수술%저체질량%성인
Modified ultrafiltration%Cardiopulmonary bypass%Cardiac surgery%Low-weight%Adult patient
目的:观察改良超滤(modified ultrafiltration,MUF)应用于低体质量成人体外循环心脏手术中的作用。方法36例接受心脏手术的患者随机分为常规体外循环组(对照组,n=18例),改良超滤组(MUF组,n=18例)。观察术前、术中、术后即刻、术后24 h红细胞比容(hematocrit,HCT),术后24 h胸腔积液引流量及围术期输血量。术后血流动力学、肺泡-动脉氧阶差(AaDO2)、呼吸机支持时间及重症监护室(intensive care unit,ICU)停留时间。结果与对照组比较,MUF组术后红细胞比容[(22.8±2.4)%vs (27.9±1.8)%,P=0.027]显著提高,出血量[(447±79) mlvs (203±71) ml,P=0.012]和输血量[红细胞(2.4±1.1) Uvs(1.0±0.2)U,P=0.008]明显下降,平均动脉压[(70±4.2)mmHgvs(81.8±9.1)mmHg,P=0.027]增加,差异均有统计学意义(P<0.05),2组正性肌力药物的使用量比较差异无统计学意义(P>0.05);AaDO2、呼吸机支持时间和ICU停留时间MUF组显著少于对照组(P<0.05)。结论在低体质量成人心脏手术中,MUF在体外循环(cardiopulmonary bypass,CPB)结束后短时间内直接滤出体内多余水分,浓缩血液,减少术后出血,降低输血量,同时改善血流动力学及呼吸功能。
目的:觀察改良超濾(modified ultrafiltration,MUF)應用于低體質量成人體外循環心髒手術中的作用。方法36例接受心髒手術的患者隨機分為常規體外循環組(對照組,n=18例),改良超濾組(MUF組,n=18例)。觀察術前、術中、術後即刻、術後24 h紅細胞比容(hematocrit,HCT),術後24 h胸腔積液引流量及圍術期輸血量。術後血流動力學、肺泡-動脈氧階差(AaDO2)、呼吸機支持時間及重癥鑑護室(intensive care unit,ICU)停留時間。結果與對照組比較,MUF組術後紅細胞比容[(22.8±2.4)%vs (27.9±1.8)%,P=0.027]顯著提高,齣血量[(447±79) mlvs (203±71) ml,P=0.012]和輸血量[紅細胞(2.4±1.1) Uvs(1.0±0.2)U,P=0.008]明顯下降,平均動脈壓[(70±4.2)mmHgvs(81.8±9.1)mmHg,P=0.027]增加,差異均有統計學意義(P<0.05),2組正性肌力藥物的使用量比較差異無統計學意義(P>0.05);AaDO2、呼吸機支持時間和ICU停留時間MUF組顯著少于對照組(P<0.05)。結論在低體質量成人心髒手術中,MUF在體外循環(cardiopulmonary bypass,CPB)結束後短時間內直接濾齣體內多餘水分,濃縮血液,減少術後齣血,降低輸血量,同時改善血流動力學及呼吸功能。
목적:관찰개량초려(modified ultrafiltration,MUF)응용우저체질량성인체외순배심장수술중적작용。방법36례접수심장수술적환자수궤분위상규체외순배조(대조조,n=18례),개량초려조(MUF조,n=18례)。관찰술전、술중、술후즉각、술후24 h홍세포비용(hematocrit,HCT),술후24 h흉강적액인류량급위술기수혈량。술후혈류동역학、폐포-동맥양계차(AaDO2)、호흡궤지지시간급중증감호실(intensive care unit,ICU)정류시간。결과여대조조비교,MUF조술후홍세포비용[(22.8±2.4)%vs (27.9±1.8)%,P=0.027]현저제고,출혈량[(447±79) mlvs (203±71) ml,P=0.012]화수혈량[홍세포(2.4±1.1) Uvs(1.0±0.2)U,P=0.008]명현하강,평균동맥압[(70±4.2)mmHgvs(81.8±9.1)mmHg,P=0.027]증가,차이균유통계학의의(P<0.05),2조정성기력약물적사용량비교차이무통계학의의(P>0.05);AaDO2、호흡궤지지시간화ICU정류시간MUF조현저소우대조조(P<0.05)。결론재저체질량성인심장수술중,MUF재체외순배(cardiopulmonary bypass,CPB)결속후단시간내직접려출체내다여수분,농축혈액,감소술후출혈,강저수혈량,동시개선혈류동역학급호흡공능。
ObjectiveTo observe the effects of modified ultrafiltration (MUF) on low-weight adults undergoing cardiac surgeries with cardiopulmonary bypass (CPB).Methods36 low-weight (<45 kg) adult patients undergoing open-heart procedure were randomized to the conventional CPB group (control group,n=18) and modified ultrafiltration group(MUF group,n=18). The following indices were analyzed: transfused blood volume during and after the operation, postoperative chest drainage, hematocrit levels before operation, during bypass, terminal of bypass and 24 hours postoperative. Also the hemodynamics, alveolar-arterial oxygen gradient (AaDO2), time to extubation and ICU-stay were observed.ResultsThe patients in MUF group had a greater rise in hematocrit [(22.8±2.4)%vs (27.9±1.8)%,P=0.027], reduce in postoperative bleeding[(447±79) mlvs (203±71) ml, P=0.012] and transfusion requirement[RBC (2.4±1.1)Uvs(1.0±0.2)U,P=0.008]. The MAP [(70±4.2) mmHgvs (81.8±9.1) mmHg,P=0.027] increased, the AaDO2 was better in MUF group (P<0.05), the dosage of inotropic drugs were significant different between two groups (P>0.05) . The time to intubation and ICU-stay was shorter in MUF group than that in control group (P<0.05).ConclusionThis study demonstrates that MUF can filtrate extra fluid directly to concentrate blood after CPB in low weight patients, reduce the blood loss effectively and blood transfusion requirements after cardiac surgery, and improve the hemodynamic and lung function.