CAJ | 학술논문

[目的]总结多发性骨髓瘤病人合并肾衰竭行血液透析治疗期间皮下注射硼替佐米的护理。[方法]对5例多发性骨髓瘤合并肾衰竭病人在行血液透析治疗同时予硼替佐米皮下注射联合地塞米松化疗，合理安排给药时间，治疗期间重视心理护理、血液透析导管的护理、用药护理、药物不良反应的护理等。[结果]完全缓解3例，部分缓解1例，因病情进展放弃治疗1例，其中最早1例入院病人肾功能恢复接近正常脱离血液透析治疗；出现的不良反应主要有外周神经病变、胃肠道反应、骨髓抑制、乏力。[结论]硼替佐米皮下注射治疗多发性骨髓瘤合并肾衰竭有较好疗效，严密观察不良反应并予及时处理，可保证病人顺利完成治疗，促进病人康复。
[목적]총결다발성골수류병인합병신쇠갈행혈액투석치료기간피하주사붕체좌미적호리。[방법]대5례다발성골수류합병신쇠갈병인재행혈액투석치료동시여붕체좌미피하주사연합지새미송화료，합리안배급약시간，치료기간중시심리호리、혈액투석도관적호리、용약호리、약물불량반응적호리등。[결과]완전완해3례，부분완해1례，인병정진전방기치료1례，기중최조1례입원병인신공능회복접근정상탈리혈액투석치료；출현적불량반응주요유외주신경병변、위장도반응、골수억제、핍력。[결론]붕체좌미피하주사치료다발성골수류합병신쇠갈유교호료효，엄밀관찰불량반응병여급시처리，가보증병인순리완성치료，촉진병인강복。
Objective:To summarize the nursing of subcutaneous injection of bortezomib therapy during hemodi-alysis for multiple myeloma patients combined with renal failure.Methods:Five patients with multiple myelo-ma combined with renal failure were treated by subcutaneous bortezomib with dexamethasone chemotherapy simultaneously during hemodialysis.To arrange the reasonable administration time and pay attention to psycho-logical care,hemodialysis catheter care,administration treatments,adverse drug reactions and other care.Re-sults:3 cases were complete remission,1 case was partial remission,and 1 case gave up treatment.The adverse reactions mainly included peripheral neuropathy,gastrointestinal reactions,bone marrow suppression,and fa-tigue.Conclusion:Bortezomib subcutaneous treatment has a good effect on multiple myeloma patients combined with renal failure.Ensured a close observation and in time treatment of adverse reactions,the patients could complete the treatment and promote the rehabilitation successfully.