中国循环杂志
中國循環雜誌
중국순배잡지
Chinese Circulation Journal
2015年
9期
872-874
,共3页
急性缺血性脑卒中%生长分化因子-15
急性缺血性腦卒中%生長分化因子-15
급성결혈성뇌졸중%생장분화인자-15
Acute ischemic stroke%Growth differentiation factor-15
目的：探讨血清生长分化因子-15（GDF-15）水平与急性缺血性脑卒中的相关性。方法：选取急性缺血性脑卒中（组）患者120例，健康体检者60例作为对照组，采用酶联免疫吸附法测定患者发病24 h的血清GDF-15水平，观察血清GDF-15水平与神经功能缺损的相关性。同时根据3个月随访时的改良Ranking量表(MRS量表)评分将120例患者分为65例残疾者（MRS≥2分）和55例非残疾者（MRS＜2分），比较两者血清GDF-15水平的差异。结果：急性缺血性脑卒中组患者血清GDF-15水平为1594（1128~2411）ng/L，高于对照组为656（507~764）ng/L，两组比较差异有统计学意义（P<0.05）。急性缺血性脑卒中组患者发病24 h 血清GDF-15水平与美国国立卫生院卒中量表评分（神经功能缺损）呈正相关（r=0.390，P<0.001）。根据3个月随访时应用的MRS量表评分显示，残疾者和非残疾者在发病24 h的血清GDF-15水平：残疾者[2411（2188~2569） ng/L]高于非残疾者[1128（980~1597） ng/L]，两者比较差异有统计学意义（Z=-5.684，P<0.001）。结论：急性缺血性脑卒中患者血清GDF-15水平高于正常人，而且与美国国立卫生院卒中量表评分有关联，血清GDF-15水平高则患者预后差。
目的：探討血清生長分化因子-15（GDF-15）水平與急性缺血性腦卒中的相關性。方法：選取急性缺血性腦卒中（組）患者120例，健康體檢者60例作為對照組，採用酶聯免疫吸附法測定患者髮病24 h的血清GDF-15水平，觀察血清GDF-15水平與神經功能缺損的相關性。同時根據3箇月隨訪時的改良Ranking量錶(MRS量錶)評分將120例患者分為65例殘疾者（MRS≥2分）和55例非殘疾者（MRS＜2分），比較兩者血清GDF-15水平的差異。結果：急性缺血性腦卒中組患者血清GDF-15水平為1594（1128~2411）ng/L，高于對照組為656（507~764）ng/L，兩組比較差異有統計學意義（P<0.05）。急性缺血性腦卒中組患者髮病24 h 血清GDF-15水平與美國國立衛生院卒中量錶評分（神經功能缺損）呈正相關（r=0.390，P<0.001）。根據3箇月隨訪時應用的MRS量錶評分顯示，殘疾者和非殘疾者在髮病24 h的血清GDF-15水平：殘疾者[2411（2188~2569） ng/L]高于非殘疾者[1128（980~1597） ng/L]，兩者比較差異有統計學意義（Z=-5.684，P<0.001）。結論：急性缺血性腦卒中患者血清GDF-15水平高于正常人，而且與美國國立衛生院卒中量錶評分有關聯，血清GDF-15水平高則患者預後差。
목적：탐토혈청생장분화인자-15（GDF-15）수평여급성결혈성뇌졸중적상관성。방법：선취급성결혈성뇌졸중（조）환자120례，건강체검자60례작위대조조，채용매련면역흡부법측정환자발병24 h적혈청GDF-15수평，관찰혈청GDF-15수평여신경공능결손적상관성。동시근거3개월수방시적개량Ranking량표(MRS량표)평분장120례환자분위65례잔질자（MRS≥2분）화55례비잔질자（MRS＜2분），비교량자혈청GDF-15수평적차이。결과：급성결혈성뇌졸중조환자혈청GDF-15수평위1594（1128~2411）ng/L，고우대조조위656（507~764）ng/L，량조비교차이유통계학의의（P<0.05）。급성결혈성뇌졸중조환자발병24 h 혈청GDF-15수평여미국국립위생원졸중량표평분（신경공능결손）정정상관（r=0.390，P<0.001）。근거3개월수방시응용적MRS량표평분현시，잔질자화비잔질자재발병24 h적혈청GDF-15수평：잔질자[2411（2188~2569） ng/L]고우비잔질자[1128（980~1597） ng/L]，량자비교차이유통계학의의（Z=-5.684，P<0.001）。결론：급성결혈성뇌졸중환자혈청GDF-15수평고우정상인，이차여미국국립위생원졸중량표평분유관련，혈청GDF-15수평고칙환자예후차。
Objective: To investigate the effect of serum growth differentiation factor-15 (GDF-15) in patients with acute ischemic stroke (AIS). Methods: Our research included 2 groups: AIS group,n=120 patients and Control group,n=60 normal subjects from regular physical examination. The serum levels of GDF-15 were examined within 24 hours of AIS attack by ELISA in both groups, the relationship between GDF-15 and the neurologic impairment was assessed. According to modiifed ranking scale score after 3 months follow-up study, the AIS patients were further divided into 2 sub-groups: Disabled group, the patients with MRS ≥ 2, n=65 and Non-disabled group, the patients with MRS < 2,n=55. The GDF-15 levels were compared between 2 sub-groups. Results: GDF-15 level in AIS group was 1594.00 (1128.00-2411.00) ng/L which was signiifcantly higher than that in Control group 656.00 (507.00-764.00) ng/L,P<0.05. GDF-15 level was positively related to neurologic impairment in AIS patients (r=0.390, P<0.001). Modiifed ranking scale score indicated that after 3 months of follow-up study, GDF-15 level in Disabled group was 2411 (2188-2569) ng/L which was much higher than that in Non-disabled group 1128 (980-1597) ng/L, (Z=-5.684,P<0.001). Conclusion: The serum level of GDF-15 was higher in AIS patients than normal subjects, it was positively related to neurologic impairment, AIS patients with higher GDF-15 would have poor prognosis.
