中国循环杂志
中國循環雜誌
중국순배잡지
Chinese Circulation Journal
2015年
9期
849-853
,共5页
杨丽睿%张慧敏%蒋雄京%邹玉宝%秦芳%宋雷%关婷%吴海英%周宪梁%卞瑾%惠汝太%郑德裕
楊麗睿%張慧敏%蔣雄京%鄒玉寶%秦芳%宋雷%關婷%吳海英%週憲樑%卞瑾%惠汝太%鄭德裕
양려예%장혜민%장웅경%추옥보%진방%송뢰%관정%오해영%주헌량%변근%혜여태%정덕유
大动脉炎%临床特点%预后
大動脈炎%臨床特點%預後
대동맥염%림상특점%예후
Takayasu’s arteritis%Clinical manifestation%Outcome
目的：探讨中国单中心566例大动脉炎患者的临床特点及预后情况。方法：回顾性分析2002-01至2013-11在我院住院的566例大动脉炎患者的临床特点、实验室检查、影像学检查、治疗策略及预后情况。结果：男女比例为1：3.8，平均发病年龄为（28.9±12.0）岁。最常见的非特异性症状、初始症状及并发症分别为发热52例（9.2%）、头晕214例（37.8%）和高血压392例（69.3%）。肺动脉和冠状动脉受累的患者分别有83例（14.7%）和66例（11.7%）。131例（23.1%）患者血沉增快。血管受累的性质以狭窄—闭塞性病变为主，最常见受累血管为左锁骨下动脉，共278例（49.1%）。治疗措施包括药物治疗、介入治疗、自体血管移植术、人工血管置换术及主动脉瓣置换术等。经过平均（5.0±0.2）年的随访，共32例患者死亡。高血压、主要并发症和疾病进展是影响大动脉炎患者预后的主要因素（回归系数分别为4.664、1.959和1.870，P均＜0.05）。结论：高血压是中国大动脉炎患者就诊的首要原因。高血压、主要并发症和疾病进展是影响大动脉炎患者预后的主要因素。由于大动脉炎与心血管事件密切相关，早期诊断和治疗至关重要。
目的：探討中國單中心566例大動脈炎患者的臨床特點及預後情況。方法：迴顧性分析2002-01至2013-11在我院住院的566例大動脈炎患者的臨床特點、實驗室檢查、影像學檢查、治療策略及預後情況。結果：男女比例為1：3.8，平均髮病年齡為（28.9±12.0）歲。最常見的非特異性癥狀、初始癥狀及併髮癥分彆為髮熱52例（9.2%）、頭暈214例（37.8%）和高血壓392例（69.3%）。肺動脈和冠狀動脈受纍的患者分彆有83例（14.7%）和66例（11.7%）。131例（23.1%）患者血沉增快。血管受纍的性質以狹窄—閉塞性病變為主，最常見受纍血管為左鎖骨下動脈，共278例（49.1%）。治療措施包括藥物治療、介入治療、自體血管移植術、人工血管置換術及主動脈瓣置換術等。經過平均（5.0±0.2）年的隨訪，共32例患者死亡。高血壓、主要併髮癥和疾病進展是影響大動脈炎患者預後的主要因素（迴歸繫數分彆為4.664、1.959和1.870，P均＜0.05）。結論：高血壓是中國大動脈炎患者就診的首要原因。高血壓、主要併髮癥和疾病進展是影響大動脈炎患者預後的主要因素。由于大動脈炎與心血管事件密切相關，早期診斷和治療至關重要。
목적：탐토중국단중심566례대동맥염환자적림상특점급예후정황。방법：회고성분석2002-01지2013-11재아원주원적566례대동맥염환자적림상특점、실험실검사、영상학검사、치료책략급예후정황。결과：남녀비례위1：3.8，평균발병년령위（28.9±12.0）세。최상견적비특이성증상、초시증상급병발증분별위발열52례（9.2%）、두훈214례（37.8%）화고혈압392례（69.3%）。폐동맥화관상동맥수루적환자분별유83례（14.7%）화66례（11.7%）。131례（23.1%）환자혈침증쾌。혈관수루적성질이협착—폐새성병변위주，최상견수루혈관위좌쇄골하동맥，공278례（49.1%）。치료조시포괄약물치료、개입치료、자체혈관이식술、인공혈관치환술급주동맥판치환술등。경과평균（5.0±0.2）년적수방，공32례환자사망。고혈압、주요병발증화질병진전시영향대동맥염환자예후적주요인소（회귀계수분별위4.664、1.959화1.870，P균＜0.05）。결론：고혈압시중국대동맥염환자취진적수요원인。고혈압、주요병발증화질병진전시영향대동맥염환자예후적주요인소。유우대동맥염여심혈관사건밀절상관，조기진단화치료지관중요。
Objective: To explore a single center large cohort of patients with Takayasu’s arteritis for their clinical manifestation and long-term outcome in China. Methods: We retrospectively analyzed 566 patients with Takayasu’s arteritis admitted in our hospital from 2002-01 to 2013-11 for their clinical characteristics, laboratory ifndings, angiographic features, treatment and long-term outcomes. Results: The patient’s ratio for female to male gender was 1 to 3.8 and the average onset age was (28.9 ± 12.0) years. The most common non-speciifc symptom, initial symptom and complication were fever (52/566 patients, 9.2%), dizziness (214 patients, 37.8%) and hypertension (392 patients, 69.3%) respectively. The patients with pulmonary artery and coronary artery involvement were 83 (14.7%) and 66 (11.7%) respectively, and 131 (23.1%) patients had faster erythrocyte sedimentation rate. The major vascular damage was steno-occlusive lesion and the most common involvement was left sub-clavian artery, which was observed in 278 (49.1%) patients. The treatments were mainly included in medication, interventional therapy, autologous blood vessel transplantation, artiifcial blood vessel transplantation and aortic valve replacement. There were 32 patients died during the mean follow-up period of (5.0 ± 0.2) years. Hypertension, complication and the progressive stage of disease were the major factors affecting prognosis in relevant patients (regression coefifcients: 4.664, 1.959 and 1.870 respectively, allP<0.05). Conclusion: Hypertension was the leading reason for patients’ hospital visit. Takayasu’s arteritis was closely related to cardiovascular disease, the early diagnosis and treatment were really important in clinical practice.
