CAJ | 학술논문

目的：比较氯普鲁卡因与利多卡因预防丙泊酚静脉注射痛的效果。方法165例接受无痛人工流产早孕患者，随机分成盐酸氯普鲁卡因组（CP组，n=55）、盐酸利多卡因组（Li组，n=55）和生理盐水组（对照组，n=55）。分别注射2% CP 4 ml、2% Li 4 ml和生理盐水4 ml，30 s后注射丙泊酚2 mg/kg，边注射边询问患者注射部位及胳膊是否疼痛，直至患者入睡。术中麻醉深度不够追加丙泊酚0.5~1.0 mg/kg。结果无注射痛CP组达92.7%，Li组60.0%，对照组43.6%（P＜0.01），且有痛的疼痛程度CP组比Li组轻，比对照组更轻。丙泊酚用量，CP组和Li组明显低于对照组（P＜0.01）。麻醉苏醒CP组和Li组比对照组快（P＜0.05）。结论氯普鲁卡因静脉预先注射对预防丙泊酚静脉注射痛效果较利多卡因好，二者也均可协同和增强丙泊酚静脉麻醉（中枢抑制）效果，且减少其用量。
목적：비교록보로잡인여리다잡인예방병박분정맥주사통적효과。방법165례접수무통인공유산조잉환자，수궤분성염산록보로잡인조（CP조，n=55）、염산리다잡인조（Li조，n=55）화생리염수조（대조조，n=55）。분별주사2% CP 4 ml、2% Li 4 ml화생리염수4 ml，30 s후주사병박분2 mg/kg，변주사변순문환자주사부위급각박시부동통，직지환자입수。술중마취심도불구추가병박분0.5~1.0 mg/kg。결과무주사통CP조체92.7%，Li조60.0%，대조조43.6%（P＜0.01），차유통적동통정도CP조비Li조경，비대조조경경。병박분용량，CP조화Li조명현저우대조조（P＜0.01）。마취소성CP조화Li조비대조조쾌（P＜0.05）。결론록보로잡인정맥예선주사대예방병박분정맥주사통효과교리다잡인호，이자야균가협동화증강병박분정맥마취（중추억제）효과，차감소기용량。
ObjectiveTo evaluate effects of chloroprocaine and lidocaine to prevent propofol injecting pain. MethodsOne hundred and sixty-five adult patients undergoing abortion were randomly divided into chloroprocaine (CP,n=55), lidocaine (Li,n=55) and normal saline (control group,n=55) groups. A dose of 4 ml was venous injected at 30 s before 2 mg/kg propofol anesthesia given by 2% CP, 2% Li or control group. 0.5~1 mg/kg was added when the depth of anesthesia was not enough.ResultsThe incidences of painlessness of propofol injection were higher (P<0.01)in group CP,accounting for 92.7%, 60.0% and 43.6% in group CP, Li and control respectively, and injecting pain grade was lower in group CP than Li and control. It was lesser significant (P<0.01) in group CP and Li than control group about propofol requirements and quicker significantly (P<0.05) in group CP and Li in waking up from anesthesia.Conclusions Chloroprocaine is better than lidocaine in preventing pain caused by propofol venous injection, and can synergy and strengthen propofol anesthesia, reducing propofol requirements in therapeutic abortion.