CAJ | 학술논문

目的：观察透明质酸修护生物膜联合他克莫司及复方倍他米松注射液治疗面部激素依赖性皮炎的临床疗效。方法60例患者随机分为两组，治疗组30例外用透明质酸修护生物膜8周，联合外用他克莫司4周，同时单次肌肉注射复方倍他米松注射液；对照组仅外用他克莫司4周，两组均口服左西替利嗪片5 mg/d。结果治疗组起效时间为（1.75±0.62）d，对照组起效时间为(6.20±1.65)d。疗程结束后4周治疗组总有效率93.33％，对照组总有效率67.86％。两组比较差异有统计学意义（P﹤0.05）。结论透明质酸修护生物膜联合他克莫司及复方倍他米松注射液治疗面部激素依赖性皮炎疗效满意，安全可靠，值得基层皮肤科医师选择应用。
목적：관찰투명질산수호생물막연합타극막사급복방배타미송주사액치료면부격소의뢰성피염적림상료효。방법60례환자수궤분위량조，치료조30예외용투명질산수호생물막8주，연합외용타극막사4주，동시단차기육주사복방배타미송주사액；대조조부외용타극막사4주，량조균구복좌서체리진편5 mg/d。결과치료조기효시간위（1.75±0.62）d，대조조기효시간위(6.20±1.65)d。료정결속후4주치료조총유효솔93.33％，대조조총유효솔67.86％。량조비교차이유통계학의의（P﹤0.05）。결론투명질산수호생물막연합타극막사급복방배타미송주사액치료면부격소의뢰성피염료효만의，안전가고，치득기층피부과의사선택응용。
ObjectiveTo observe the outcome of hyaluronan-containing emulsion , tacrolimus and diprospan used together to treat facial corticosteroid addictive dermatitis. Methods 60 patients were randomly divided into two groups. Treatment group (30 cases) received hyaluronan-containing emulsion for 8 weeks and tacrolimus for 4 weeks with diprospan injected at the same time. Control group was only treated with tacrolimus for 4 weeks. Both groups took Levocetirizine Dihydrochloride Tablets 5mg/d.Results Onset time is (1.75±0.62) d in treatment group while it is (6.20±1.65)d in the other group. After 4 weeks’ treatment, the effectiveness of treatment group is 93.33% which is better than 67.86% in control group. Thedifferences were statistical significant (p<0.05). Conclusion Hyaluronan-containing emulsion combined with tacrolimus and diprospan are safe and effective for treating facial corticosteroid addictive dermatitis.