CAJ | 학술논문

肝移植作为治疗终末期肝病的唯一有效手段,其临床应用已逾半个世纪,而供肝来源的短缺一直是限制其发展的瓶颈.在为数不多的供肝中,如何确定其质量以保证移植患者的预后为目前研究的主要方向.脑死亡造成的全身脏器病理生理改变亦包括肝脏.为此,如何进行相关病理学及血清学检查以确定肝脏使用的安全性十分重要.本文对近年发表的相关文献进行综合、分析,对供体器官质量评价指标进行综述.以期对捐献供体肝脏进行有效评价以利于临床工作.
간이식작위치료종말기간병적유일유효수단,기림상응용이유반개세기,이공간래원적단결일직시한제기발전적병경.재위수불다적공간중,여하학정기질량이보증이식환자적예후위목전연구적주요방향.뇌사망조성적전신장기병리생리개변역포괄간장.위차,여하진행상관병이학급혈청학검사이학정간장사용적안전성십분중요.본문대근년발표적상관문헌진행종합、분석,대공체기관질량평개지표진행종술.이기대연헌공체간장진행유효평개이리우림상공작.
Liver transplantation,a unique effective treatment for end-stage liver diseases,has already been applied in clinical practice for more than half a century.But the shortage of donor liver source has been the bottleneck limiting its development.How to determine the tiny minority donor liver quality to guarantee the prognosis of transplant patients becomes a hot focus for current research.Brain death causes patho-physiological changes of body organs,including liver.How to carry out related pathological and serologic tests to determine the safety of the donor liver is a very important issue.In this paper,the articles published in recent years were overviewed and analyzed to summarize the evaluation index of donating organ quality.We hope this paper may benefit the treatment through ensuring an effective evaluation on the donor liver in the future.