CAJ | 학술논문

目的：探讨葛根素联合左卡尼汀对小儿病毒性心肌炎的临床疗效。方法：选择病毒性心肌炎患儿71例，随机分为对照组（35例）及治疗组（36例），分别采用常规治疗及在此基础上的葛根素联合左卡尼汀治疗，对两组患儿治疗后氧化应激水平、心肌酶进行测定。结果：治疗组治疗后MDA、SOD、GSH较治疗前出现显著性差异（P＜0．05），治疗组治疗后MDA、SOD、GSH较对照组均有显著差异（P＜0．05）。对照组治疗后CK‐MB及cTnT 较治疗前均有显著性下降（P＜0．05），治疗组治疗后CK‐MB、cTnT 及cTnI较治疗前出现显著性下降（P＜0．05）。治疗组治疗后CK‐MB、cTnT 及cTnI较对照组均有显著下降（P＜0．05）。相关性分析示cTnT与SOD及GSH显著负相关（P＜0．05），cTnI与SOD及GSH显著负相关，与MDA呈显著正相关（P＜0．05）。结论：葛根素联合左卡尼汀可有效降低氧化应激及心肌酶水平，且氧化应激水平与心肌酶水平密切相关。
목적：탐토갈근소연합좌잡니정대소인병독성심기염적림상료효。방법：선택병독성심기염환인71례，수궤분위대조조（35례）급치료조（36례），분별채용상규치료급재차기출상적갈근소연합좌잡니정치료，대량조환인치료후양화응격수평、심기매진행측정。결과：치료조치료후MDA、SOD、GSH교치료전출현현저성차이（P＜0．05），치료조치료후MDA、SOD、GSH교대조조균유현저차이（P＜0．05）。대조조치료후CK‐MB급cTnT 교치료전균유현저성하강（P＜0．05），치료조치료후CK‐MB、cTnT 급cTnI교치료전출현현저성하강（P＜0．05）。치료조치료후CK‐MB、cTnT 급cTnI교대조조균유현저하강（P＜0．05）。상관성분석시cTnT여SOD급GSH현저부상관（P＜0．05），cTnI여SOD급GSH현저부상관，여MDA정현저정상관（P＜0．05）。결론：갈근소연합좌잡니정가유효강저양화응격급심기매수평，차양화응격수평여심기매수평밀절상관。
Objective:To investigate the clinical efficacy of Pueraria factors combined with L‐carnitine in chil‐dren with viral myocarditis .Methods :71 cases of children with viral myocarditis were randomly divided into control group (35 cases) and observation group (36 cases) ,which accepted conventional therapy and Puerarin combined L‐carni‐tine therapy ,oxidative stress ,cardiac enzymes were measured .Results :MDA ,SOD ,GSH in the observation group after treatment than before treatment were significantly different (P<0 .05) ,MDA ,SOD ,GSH of observation group com‐pared with the control group were significantly different (P<0 .05) .CK‐MB and cTnT in the control group significantly decreased than before treatment(P<0 .05) ,CK‐MB ,cTnT and cTnI in the observation group significantly decreased than before treatment(P<0 .05) .CK‐MB ,cTnT and cTnI of the observation group compared with the control group signifi‐cantly decreased (P <0 .05) .Correlation analysis showed that SOD and GSH had significant negative correlation with cTnT (P <0 .05) ,SOD and GSH had significant negative correlation with cTnI (P <0 .05) ,and showed significant pos‐itive correlation with MDA (P<0 .05) .Conclusion :Puerarin combined with L‐carnitine can reduce oxidative stress and cardiac enzymes ,and oxidative stress and cardiac enzymes are closely related .