CAJ | 학술논문

抗生素的滥用导致世界范围内细菌耐药性的出现和流行。许多临床上本来起作用的抗生素失效，这为细菌感染性疾病的治疗带来了巨大困难。近年来研究发现，细菌细胞分裂蛋白细丝温度敏感蛋白 Z（FtsZ）在细胞分裂中发挥着重要的作用，它被认为是一个非常有潜力的抗菌药物靶点。已经发现，一些抗菌天然产物作用于该靶点。本文主要阐述 FtsZ 蛋白的结构和功能，以及一些以细丝温度敏感蛋白 Z 蛋白为靶点的抗菌天然产物的研究进展，以期为研发新型抗菌药物提供基础。
항생소적람용도치세계범위내세균내약성적출현화류행。허다림상상본래기작용적항생소실효，저위세균감염성질병적치료대래료거대곤난。근년래연구발현，세균세포분렬단백세사온도민감단백 Z（FtsZ）재세포분렬중발휘착중요적작용，타피인위시일개비상유잠력적항균약물파점。이경발현，일사항균천연산물작용우해파점。본문주요천술 FtsZ 단백적결구화공능，이급일사이세사온도민감단백 Z 단백위파점적항균천연산물적연구진전，이기위연발신형항균약물제공기출。
The misuse of antibiotics has resulted in the emergence and prevalence of bacterial resistance around the world. Many originally powerful antibiotics in the clinic have shown either weak or no activity against resistant strains,which contributes to enormous difficulties in fighting bacterial infections. In recent years,the study has found that filamentous tem-perature - sensitive protein Z(FtsZ)plays an important role in bacterial cell division,so FtsZ protein is considered as a very potential target for antibacterial agents. Some antimicrobial natural products have been found to act on the target. In this paper,the structure and function of FtsZ protein and the antimicrobial natural products were introduced so as to provide the basis for the research and development of new antibacterial drugs.