CAJ | 학술논문

目的了解浙江省宁波市长期食用非碘盐居民碘营养水平、甲状腺功能和甲状腺结节患病状况.方法 2011年,采用典型抽样法抽取宁波市6个长期食用非碘盐行政村/社区的6 ～ 70岁居民作为调查对象,进行尿碘检测、甲状腺B超检查及甲状腺功能检测[血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)],尿碘检测采用砷铈催化分光光度法,甲状腺功能检查采用化学发光法.结果共调查1 177人,其中男性482人,女性695人(孕妇2名),平均年龄为(48.54±13.98)岁.居民尿碘中位数为90.36μg/L,其中尿碘＜100 μg/L人群的比例为56.07％(660/1 177);男性尿碘中位数为97.05 μg/L,女性尿碘中位数为83.84 μg/L,二者比较差异有统计学意义(Z=-2.99,P＜0.05);各年龄组人群尿碘水平比较,组间比较差异有统计学意义(x2=99.34,P＜ 0.01).甲状腺结节检出率为19.88％,标化率为13.95％.其中男性甲状腺结节检出率为11.83％,标化率为8.11％;女性检出率为25.47％,标化率为19.83％.不同性别人群甲状腺结节检出率比较差异有统计学意义(x2=33.25,P＜0.01);各年龄组人群甲状腺结节检出率比较,差异有统计学意义(x2=49.65,P＜ 0.01),且检出率随年龄增大呈上升趋势(x2趋势=44.22,P＜0.01).结论宁波市食用非碘盐社区居民碘营养水平较低,甲状腺结节检出率女性高于男性,随年龄增大呈上升趋势.
목적 료해절강성저파시장기식용비전염거민전영양수평、갑상선공능화갑상선결절환병상황.방법 2011년,채용전형추양법추취저파시6개장기식용비전염행정촌/사구적6 ～ 70세거민작위조사대상,진행뇨전검측、갑상선B초검사급갑상선공능검측[혈청유리삼전갑상선원안산(FT3)、유리갑상선소(FT4)、촉갑상선격소(TSH)、갑상선과양화물매항체(TPOAb)、갑상선구단백항체(TGAb)],뇨전검측채용신시최화분광광도법,갑상선공능검사채용화학발광법.결과 공조사1 177인,기중남성482인,녀성695인(잉부2명),평균년령위(48.54±13.98)세.거민뇨전중위수위90.36μg/L,기중뇨전＜100 μg/L인군적비례위56.07％(660/1 177);남성뇨전중위수위97.05 μg/L,녀성뇨전중위수위83.84 μg/L,이자비교차이유통계학의의(Z=-2.99,P＜0.05);각년령조인군뇨전수평비교,조간비교차이유통계학의의(x2=99.34,P＜ 0.01).갑상선결절검출솔위19.88％,표화솔위13.95％.기중남성갑상선결절검출솔위11.83％,표화솔위8.11％;녀성검출솔위25.47％,표화솔위19.83％.불동성별인군갑상선결절검출솔비교차이유통계학의의(x2=33.25,P＜0.01);각년령조인군갑상선결절검출솔비교,차이유통계학의의(x2=49.65,P＜ 0.01),차검출솔수년령증대정상승추세(x2추세=44.22,P＜0.01).결론 저파시식용비전염사구거민전영양수평교저,갑상선결절검출솔녀성고우남성,수년령증대정상승추세.
Objective To investigate the iodine nutritional status,thyroid function and the prevalence of thyroid nodules of residents using non-iodized salt in Ningbo City,Zhejiang Province.Methods In 2011,using typical sampling method,6 villages/communities consumption of non-iodized salt were selected as study fields and residents aged 6-70 were selected as study subjects in Ningbo.Urinary iodine detection,thyroid ultrasound examination and tests of thyroid function [free triiodothyronine (FT3),free thyroxine (FT4),thyroid stimulating hormone (TSH),thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb)] were performed in all participants.Urinary iodine concentration (UIC) was determined by arsenic cerium catalytic spectrophotometry,and thyroid function was monitored by chemiluminescence method.Results A total of 1 177 residents agreed to participate in the study,482 were male,and 695 were female (including 2 pregnant women).The participants' mean age was (48.54 ± 13.98) years.The median UIC in all participants was 90.36 μg/L,and the proportions with a UIC ＜ 100μg/L was 56.07％ (660/1 177).Furthermore,the median UIC in male was 97.05 μg/L and in female was 83.84 μg/L,there was a significant difference in UICs between male and female (Z =-2.99,P ＜ 0.05).Similarly,significant difference in UICs was observed among age groups (x2 =99.34,P ＜ 0.01).Among the participants,19.88％ had thyroid nodules,with standardized prevalence rate of 13.95％.Furthermore,in male,11.83％ had thyroid nodules,with standardized prevalence rate of 8.11％,and in female was 25.47％,with standardized prevalence rate of 19.83％,there was a significant difference in the detection rate of thyroid nodules between male and female (x2 =33.25,P ＜ 0.01).Likewise,significant difference in the detection rate of thyroid nodules was observed among age groups (x2=49.65,P＜ 0.01),and there was a positive and significant correlation between the detection rate of thyroid nodules and increasing age (x2trend =44.22,P ＜ 0.01).Conclusions The residents who using non-iodized salt in Ningbo City are in the status of iodine deficiency.The detection rate of thyroid nodules is higher in female than in male and it has increased with age.