皖南医学院学报
皖南醫學院學報
환남의학원학보
Acta Academiae Medicinae Wannan
2015年
5期
469-471
,共3页
腺鳞癌%胰腺肿瘤%治疗%预后
腺鱗癌%胰腺腫瘤%治療%預後
선린암%이선종류%치료%예후
adenosquamous carcinoma%pancreatic neoplasia%treatment%prognosis
目的：探讨胰腺腺鳞癌的临床特征、病理学特点及治疗方法。方法：回顾性分析2012年1月～2014年12月本院诊治的5例胰腺腺鳞癌患者的临床特点并文献复习。结果：5例胰腺腺鳞癌患者中，男性3例，女性2例，肿瘤位于胰头3例，胰体尾部2例，5例患者均行手术治疗，术后病理示：2例胰头癌侵犯十二指肠，1例胰体尾癌侵犯胃壁肌层，1例侵犯肠系膜上静脉，2例神经见侵犯，2例有淋巴结转移。4例术后生存4～8个月，平均生存（5．9±1．5）个月，均死于肿瘤复发及转移。目前存活的1例患者于2014年11月4日行手术，术后行辅助化疗，3周期复查提示肝脏及胰周淋巴结转移。结论：胰腺腺鳞癌是一种较为罕见的胰腺恶性肿瘤，容易出现局部组织、神经、脉管侵犯以及肝脏和远处转移，预后差，可以通过早期诊断及手术结合放化疗提高疗效。
目的：探討胰腺腺鱗癌的臨床特徵、病理學特點及治療方法。方法：迴顧性分析2012年1月～2014年12月本院診治的5例胰腺腺鱗癌患者的臨床特點併文獻複習。結果：5例胰腺腺鱗癌患者中，男性3例，女性2例，腫瘤位于胰頭3例，胰體尾部2例，5例患者均行手術治療，術後病理示：2例胰頭癌侵犯十二指腸，1例胰體尾癌侵犯胃壁肌層，1例侵犯腸繫膜上靜脈，2例神經見侵犯，2例有淋巴結轉移。4例術後生存4～8箇月，平均生存（5．9±1．5）箇月，均死于腫瘤複髮及轉移。目前存活的1例患者于2014年11月4日行手術，術後行輔助化療，3週期複查提示肝髒及胰週淋巴結轉移。結論：胰腺腺鱗癌是一種較為罕見的胰腺噁性腫瘤，容易齣現跼部組織、神經、脈管侵犯以及肝髒和遠處轉移，預後差，可以通過早期診斷及手術結閤放化療提高療效。
목적：탐토이선선린암적림상특정、병이학특점급치료방법。방법：회고성분석2012년1월～2014년12월본원진치적5례이선선린암환자적림상특점병문헌복습。결과：5례이선선린암환자중，남성3례，녀성2례，종류위우이두3례，이체미부2례，5례환자균행수술치료，술후병리시：2례이두암침범십이지장，1례이체미암침범위벽기층，1례침범장계막상정맥，2례신경견침범，2례유림파결전이。4례술후생존4～8개월，평균생존（5．9±1．5）개월，균사우종류복발급전이。목전존활적1례환자우2014년11월4일행수술，술후행보조화료，3주기복사제시간장급이주림파결전이。결론：이선선린암시일충교위한견적이선악성종류，용역출현국부조직、신경、맥관침범이급간장화원처전이，예후차，가이통과조기진단급수술결합방화료제고료효。
Objective:To investigate the clinical characteristics, pathological behavior and treatment of adenosquamous carcinoma of the pancreas. Methods:A retrospective analysis was performed in 5 cases of adenosquamous carcinoma of the pancreas treated in our hospital during January 2012 and December 2014,and related literatures were reviewed.Results:In the 5 cases,3 were men,and 2 women.Focal area was seen in the head of the pancreas in 3 cases,and body and tail in 2.And the tumors were surgically resected in 5 patients.Postoperative pathology showed that duodenal invasion occurred in 2 cases of the head of the pancreas,gastric muscular layer invasion in 1 case of body and tail of the pancreas,superior mesenteric vein invasion in 1,neural involvement in 2 and lymphatic metastasis in 2.Postoperative survival was 4 to 8 months for 4 patients(mean 5.9 ±1.5),who died of recurrence and liver metastasis.The only one survival received surgery on November 4,2014 and postoperative adjuvant chemotherapy.Re-examination after three cycles of chemotherapy revealed liver and peri-pancreatic lymph node metastasis .Conclusion:Adenosquamous carcinoma of the pancreas is rare malignant entity , and tends to involve local tissues,peripheral nerves and veins,with likeliness of liver and distal metastasis as well as poorer prognosis .However,early diag-nosis and timely surgery with radiotherapy and chemotherapy may improve the survival rate .
